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Annals of Oncology 8:S15-S17, 1997
© 1997 European Society for Medical Oncology

Treatment of childhood Hodgkin's disease without radiotherapy

H. van den Berg1, J. Zsiros and H. Behrendt

Emma Kinderziekenhuts AMC, University of Amsterdam the Netherlands

1Correspondence to: H. van den Berg, MD, PhD Emma Kinderzienkeuis AMC Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands

Background To minimize the side effects of treatment in children with Hodgkin's disease (HD), chemotherapy was given without radiotherapy.

Patients and methods From 1975 to 1984, 21 patients with HD having lymph nodes <4 cm were treated with six MOPP courses. From 1984 to 1987, all children presenting with HD (n = 17) were given six ABVD courses. From 1987 to 1993 all children (n = 21) were treated with six alternating ABVD and MOPP courses.

Results MOPP-treated children showed an event-free survival (EFS) of 91%, overall survival, 100%; ABVD-treated children had an EFS of 70%, overall survival, 94%; ABVD-MOPP-treated children had an EFS of 91% and an overall survival of 91%. Two cases developed a second malignancy. Toxicity was low.

Conclusions In children, ABVD-MOPP treatment gives a good survival, and toxicity is low. Radiotherapy is not needed to treat HD in children.

chemotherapy, children, Hodgkin's disease, late effects, secondary tumors


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