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Annals of Oncology 7:S3-S12, 1996
© 1996 European Society for Medical Oncology

Reviews

New classification of low-grade lymphoma

T. M. Grogan

Department of Pathology, University of Arizona Tucson, AZ, USA

Correspondence to: Thomas M. Grogan, MD Department of Pathology University of Arizona 1501 N Campbell Avenue Tucson, AZ 85724, USA

The problem of morphologic classification of the indolent non-Hodgkin's lymphomas has been addressed by the National Cancer Institute Working Formulation, the International Lymphoma Study Group, and other groups. The criteria for classification have expanded to include biologic and laboratory parameters. Clinical aspects are important, because diagnostic categories that obscure discrete entities, such as mucosa-associated B-cell lymphoma could adversely affect therapy. This and other indolent non-Hodgkin's lymphomas and mantle-cell lymphoma, which has been provisionally included among them, are reviewed. Variations in nomenclature, immunohistochemical and molecular characteristics, and whenever possible, prognosis and clinical outcome are described. The need for further correlation with clinical outcome of these entities is noted.

B-cell lymphoma, MALToma, non-Hodgkin's lymphoma, Working Formulation


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