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Annals of Oncology 7:S61-S65, 1996
© 1996 European Society for Medical Oncology

Symposium Article

Lymphocyte predominant Hodgkin's disease — a workshop report

M. Sextro1, V. Diehl1, J. Franklin1, M.-L. Hansmann2, I. Anagnostopoulos, T. Marafioti, H. Stein and European Task Force on Lymphoma

1 Klinik I für Innere Medizin der Universität zu Köln Berlin, Germany
2 Institut für Pathologic der Universität zu Kön Köln, Berlin, Germany
Freie Univcrsität Berlin, Universitätsklinikun Benjamin Franklin, Institut für Pathologic Berlin, Germany

Correspondence to: Michael Sextro, M.D. Klinik für Innere Medizin der Universität zu Köln Joseph-Stelzmann-Str.9 D-50924 Köln Germany

Since lymphocyte predominant Hodgkin's disease (LPHD) may comprise more than one entity, diagnostic criteria, clinical features, and treatment strategies are still being controversially discussed. Thus, in December 1994 a multinational project on lymphocyte predominant Hodgkin's disease was initiated by the European Task Force on Lymphoma. This project is aimed at clarifying the clinical and histopathological spectrum of LPHD, as well as its relation to T-cellrich B-cell lymphoma and classical types of HD.525 paraffin blocks and clinical data of 478 patients from 16 international centres were submitted. At the Third International Symposium on Hodgkin's Lymphoma in Cologne, 232 of these cases were discussed by an expert panel. The preliminary results are presented here. Most cases of LPHD were reclassified into nodular paragranuloma (NP) and lymphocyte rich classical HD. In both groups, a considerable number of cases with atypical features was observed. Few cases of NEL were found among the cohort. LPHD was generally treated according to common standards for ND. The whole group of LPHD did not have a better prognosis than NS; whereas early stage NP did perform better than early stage NS (data from the German Hodgkin's Lymphoma Study Group). There is however a striking discrepancy between good survival and the frequent relapses observed in NP which needs to be elucidated.

histopathology, lymphocyte predominance Hodgkin's disease, paragranuloma, prognosis


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