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Annals of Oncology 7:S5-S10, 1996
© 1996 European Society for Medical Oncology

Reviews

Epidemiology of EBV and Hodgkin's lymphoma

A. F. Jarrett1, A. A. Armstrong1 and E. Alexander2

1 Leukaemia Research Fund Virus Centre, Department of Veterinary Pathology, Veterinary School, University of Glasgow Glasgow
2 Department of Public Health, University of Edinburgh Medical School Teviot Place, Edinburgh, U.K.

Correspondence to: Ruth F. Jarrett Leukaemia Research Fund Virus Centre Department of Veterinary Pathology Veterinary School University of Glasgow Glasgow G6l 1QH, U.K.

The incidence of Hodgkin's disease shows marked heterogeneity with respect to age, gender, race, geographical locale, social class and histological subtype. The Epstein-Barr virus (EBV) is associated with a proportion of cases, approximately 40% in developed countries, and there is a body of evidence which suggests that mixed cellularity Hodgkin's disease is more likely to be EBV-associated than nodular sclerosis Hodgkin's disease. This study investigates the relationship between EBV and both age and histological subtype. We confirm the above subtype distribution and that childhood and older adult cases are more likely to be EBV-associated than young adult cases. Young adult nodular sclerosis cases are rarely EBV-associated providing further evidence that this is a separate disease entity. The results of this study support the multiple aetiology hypothesis which suggests that Hodgkin's disease in different age groups has different aetiologies. The epidemiology of Hodgkin's disease and studies investigating the distribution of EBV-associated cases are reviewed.

aetiology, epidemiology, Epstein-Barr virus, Hodgkin's lymphoma


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