Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Deerberg-Wittram, J.
Right arrow Articles by Schlegelberger, B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Deerberg-Wittram, J.
Right arrow Articles by Schlegelberger, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Annals of Oncology 7:S49-S53, 1996
© 1996 European Society for Medical Oncology

Reviews

Cytogenetics and molecular cytogenetics in Hodgkin's disease

J. Deerberg-Wittram, K. Weber-Matthiesen and B. Schlegelberger

Department of Human Genetics, University of Kiel Kiel Germany

Correspondence to: Klaus Weber-Matthiesen, M.D. Department of Human Genetics University of Kiel Schwanenweg 24 24105 Kiel Germany

For about 20 years we have known from cytogenetic studies that there is a clonal cell population in Hodgkin's disease. Most karyotypes are complexly aberrant and chromosome numbers typically lie in the hyperploid range. Some chromosome regions seem to be preferentially involved, but a chromosome aberration specific for Hodgkin's disease has not yet been determined. Although the existence of a clonal cell population is evident from these cytogenetic studies, there is still an ongoing debate, whether in all cases the pathognomonic Hodgkin and Reed-Stemberg cells belong to one single aberrant clone and thus represent a monoclonal proliferation. This article reviews the current knowledge on cytogenetics in Hodgkin's disease. Moreover, our recent data from simultaneous immunophenotyping and interphase cytogenetics (FICTION) are introduced into the passionate discussion on the monoclonality of the Hodgkin and Reed-Sternberg cells.

cytogenetics, FICTION, FISH, Hodgkin's disease


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.