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Annals of Oncology 7:S45-S47, 1996
© 1996 European Society for Medical Oncology


Symposium Article

Report on the Workshop Biology of the Third International Symposium on Hodgkin's Lymphoma in Cologne 1995

J. Wolf, H. Bohien and V. Diehi

Klinik I für Innere Medizin, Köln Germany

Correspondence to: Dr. J. Wolf Klinik I für Innere Medizin Joseph-Stelzmannstr. 9 D-50924 Köln Germany

Micromanipulation of single Hodgkin-Reed/Sternberg cells and subsequent nucleic acid amplification (H—RS single cell PCR) has now been established as a new and powerful method for specific genetic analysis of the tumor cells in Hodgkin's disease (HD). Although there are still some discrepancies in the results presented by different groups, most probably due to methodological problems, H-RS cells, at least in a substantial proportion of cases, seem to be B-lyrnphoid cells of monoclonal origin. In addition, new data were presented on the cytokine/cytokine receptor interaction in HD, on transcription factors in HD-derived cell lines and on a promising approach for identification of tumor associated antigens in HD.

biology, CD30, Epstein-Barr virus, Hodgkin's disease


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