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Annals of Oncology 7:S27-S30, 1996
© 1996 European Society for Medical Oncology

Reviews

Single cell analysis of Hodgkin/Reed–Sternberg cells

R. Küppers1, H. Kanzler1,2, M.-L. Hansmann2 and K. Rajewsky1

1 Institute for Genetics, University of Cologne Cologne, Germany
2 Department of Pathology, University of Cologne Cologne, Germany

Correspondence to: Ralf Küppers, Ph.D. University of Cologne LFI-Building, E4 R706 Josef-Stelzmann-Str. 9 50931 Cologne, Germany

The origin and clonality of the Hodgkin and Reed-Stemberg (HRS) cells in Hodgkin's disease (HD) has been much debated. Recently, single cell PCR techniques were established, allowing the study of HRS cells at the single cell level. HRS cells were analysed for Ig gene rearrangements to reveal a potential origin from B lineage cells. Whereas one study did not detect any V gene rearrangements, such rearrangements were found in three other investigations. However, whereas our own group detected clonal V gene rearrangements in the HRS cells of 11 (10 classical and one lymphocyte predominant) out of 12 cases of HD and no rearrangements in the twelfth, Delabie et al. (Blood 1994; 84: 3291-8) described four cases of lymphocyte predominant HD with polyclonal V gene rearrangements and Hummel and colleagues detected monoclonal as well as polyclonal and ‘mixed’ populations of HRS cells in cases of classical HD. Potential reasons for the differing results of those investigations are discussed.

Hodgkin's disease, Ig gene rearrangements, micromanipulation, Reed-Sternberg cell, single cell PCR


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