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Annals of Oncology 7:S135-S141, 1996
© 1996 European Society for Medical Oncology

Reviews

Development of immunotoxins for potential clinical use in Hodgkin's disease

S. Barth, R. Schnell, V. Diehi and A. Engert

Klinik I für Innere Medizin, Universität zu Köln, Köln Germany

Correspondence to: A. Engert, M.D. Klinik I für Innere Medizin University of Cologne Joseph-Stelzmann-Str. 9 D-50924 Köln Germany

During the last decade, immunotoxins (ITs) consisting of a cell-binding moiety and a potent toxin were developed as a new class of biological anti-tumor agents. Hodgkin's disease has shown to be one of the best targets for immunotoxins, as lymphocyte activation markers such as CD25 and CD30 are expressed on Hodgkin and Reed-Sternberg (H-RS)-cells in large numbers. Several inimunotoxins against these antigens, which are expressed physiologically only on a small subset of activated hematopoietic cells have demonstrated potent antitumor effects both, in vitro and in animal models. Here we summarize the experimental and recent clinical data of using ifs in Hodgkin's disease.

immunotoxin, RFT5-SMPT-dgA, DAB486IL-2, Ber-H2/saporin, Hodgkin's disease, review


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