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Annals of Oncology 7:145-150, 1996
© 1996 European Society for Medical Oncology

research-article

Clinical stage I and II Hodgkin's disease: Long-term results of therapy without laparotomy

Experience at one institution

A. Foss Abrahamsen1, E. Hannisdal1, O. Nome1, H. Holte1, B. Hager2, R Langholm3 and S. Kvaløy1

1Department of Medical Oncology and Radiotherapy Oslo, Norway
2Department of Diagnostic Radiology Oslo, Norway
3Department of Pathology, The Norwegian Radium Hospital Oslo, Norway

A. Foss Abrahamsen, M.D. The Norwegian Radium Hospital Montebello 0310 Oslo Norway

Background: We concluded a program in which we administered radiotherapy only to clinical stages I and II Hodgkin's disease patients at standard risk, with the addition of 4 cycles of combination chemotherapy before radiotherapy for high-risk patients.

Patients and methods: From 1980 to 1991, 313 patients with clinical stages I or II Hodgkin's disease underwent treatment in our hospital. Fifty percent of the patients in groups previously identified as being at high risk for relapse received 4 cycles of combination chemotherapy before radiotherapy. The remaining half of the patients received radiotherapy only.

Results: Low- and high-risk patients aged 15–59 years had, respectively, complete remission (CR) rates of 97% and 94%, 5-year survivals of 95% and 91%, and 5-year freedom from relapse (FFR) rates of 78% and 89%. Older low- and high-risk groups had CR rates of 97% and 93%, 5-year survivals of 60% and 56% and 5-year FFR of 77% and 93%, respectively.

Conclusion: Here we present our favorable results after treating standard-risk patients with clinical stages I and II Hodgkin's disease with radiotherapy only. With the addition of chemotherapy, the rate of relapse in the high-risk patients was reduced below that of the standard-risk patients. Overall survival was the same for the high- and standard-risk patients.

adjuvant chemotherapy, Hodgkin's disease, radiotherapy, stages I and II


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