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Annals of Oncology 7:1023-1027, 1996
© 1996 European Society for Medical Oncology

research-article

Clinical significance of bcl-2 (MBR)/JH rearrangement in the peripheral blood of patients with diffuse large B-cell lymphomas

E. Zucca1,, F. Bertoni1, G. Bosshard1, E. Roggero1, E. Ceresa1, P. Sanna1, E. Pedrinis2 and F. Cavalli1

1Servizio Oncologico Cantonale, Ospedale San Giovanni Bellinzona
2Istituto Cantonale di Patologia Locarno, Switzerland

Correspondence to: Emanuele Zucca, MD Servizio Oncologico Cantonale, Ospedale San Giovanni, 6500 Bellinzona Switzerland

BACKGROUND:: Approximately one-fourth of diffuse large B-cell lymphomas (DLCL) carry the bcl-2(MBR)/JH rearrangement caused by the t(14;18) translocation. The clinical sigmlicance of this rearrangement in patients with DLCL remains controversial. By polymerase chain reaction (PCR) we prospectively evaluated the prognostic relevance of the bcl-2 (MBR)/JH rearrangement present in circulating B-cells at the time of diagnosis.

MATERIALS AND METHODS:: The bcl-2 (MBR)/JH rearrangement was analysed by a nested-PCR method in peripheral blood samples of 51 HIV-negative patients with previously untreated DLCL .

RESULTS:: The bcl-2 (MBR)/JH rearrangement was detected in 16 cases (31%). Peripheral blood bcl-2 (MBR)/JH rearrangement detection by PCR at diagnosis was correlated with poor overall survival, lymphoma-specific survival and time to progression (log-rank P < 0.05). There was no statistically sigdicant difference between the clinical characteristics at presentation of bcl-2/JH-positive and negative patients.

CONCLUSIONS:: The peripheral blood is a readily accessible tissue for this type of analysis, and this study indicates that detection of the t (14;18) translocation at presentation in the blood of patients with DLCL may presage a poor prognosis.

bcl-2, gene rearrangement, large cell lymphoma, PCR, prognostic factors, t(14;18)


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