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Annals of Oncology 6:795-800, 1995
© 1995 European Society for Medical Oncology

research-article

Can clinical data help to screen patients with lymphoma for MR imaging of bone marrow?

A. A. Tardivon1,7, J.-N. Munck2, L. G. Shapeero1,6, S. Koscielny3, J. Bosq4, F. Dhermain5, R. Gilles1, M. Hayat2 and D. Vanel1

1Department of Radiology, Institut Gustave Roussy Villejuif, France
2Department of Hematology, Institut Gustave Roussy Villejuif, France
3Department of Statistics, Institut Gustave Roussy Villejuif, France
4Department of Pathology, Institut Gustave Roussy Villejuif, France
5Department of Radiotherapy, Institut Gustave Roussy Villejuif, France
6Department of Radiology University of California San Francisco, CA, U.S.A

7Correspondence to: Dr. Anna Johnson Department of Oncology University Hospital S-221 85 Lund Sweden

Background: Previous studies have suggested combining magnetic resonance (MR) imaging and biopsy in patients with lymphoma but associations between MR results and clinical symptoms have never been investigated. The purpose of this retrospective study was to better delineate patients profiles requiring bone marrow (BM) imaging in lymphoma

Materials and methods: 50 MR studies and blind biopsies (BB) were reviewed in 40 patients with lymphoma. MR results were compared to clinical, laboratory-based and BM follow-up data to determine potential associations between MR results and these parameters

Results: 46% of MR studies were abnormal with a normal BB; 2% were normal with an abnormal BB. Abnormal MR results were significantly associated with subsequent bone marrow involvement (p<0.01). Abnormal MR studies were significantly associated with constitutional symptoms, bone pains (p<0.05) and an elevated alkaline phosphatase level (p < 0.01). MR imaging excluded malignancy in three patients and caused therapy to be modified in three

Conclusions: Abnormal clinical and laboratory-based data should be used to screen patients with normal BB for MR imaging, especially in patients with Hodgkin's disease and high grade non-Hodgkin's lymphoma

biopsy, bone marrow, comparative studies, lymphoma, magnetic resonance studies


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