Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (42)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cormio, G.
Right arrow Articles by Bonazzi, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cormio, G.
Right arrow Articles by Bonazzi, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Annals of Oncology 6:571-574, 1995
© 1995 European Society for Medical Oncology

research-article

Central nervous system metastases in patients with ovarian carcinoma

G. Cormio2, A. Maneo1,, G. Parma1, M. R. Pittelli1, M. D. Miceli1 and C. Bonazzi1

1Department Clinica Ostetrica e Ginecologica-Università degli Studi di Milano, Istituto di Scienze Biomediche, Ospedale S. Cerardo, Monza
2Patologia Ostetrica e Ginecologica-Universita degli Studi di Ban Italy

Correspondence to: Andrea Maneo, M.D. Ostetricia e Ginecologia Ospedale S. Gerardo Via Solferino 16 20052 Monza (Milano) Italy

BACKGROUND: Central nervous system (CNS) involvement by ovarian carcinoma is rare.

PATIENTS AND METHODS: From September 1982 to September 1994, 23 patients with CNS metastases from ovarian carcinoma were observed in our institution.

RESULTS: Their median age at the time of CNS metastasis diagnosis was 59 years, and the median interval between diagnosis of ovarian cancer and documentation of the metastasis was 35 months. The most common symptoms related to CNS involvement were motor weakness, headache, seizures, dizziness and visual disturbances. One patient had meningeal carcinomatosis; 22 had parenchyma] lesions (18 cerebral and 4 cerebellar). Nine patients had a single CNS lesion, and 13 had multiple metastatic sites. CNS was the only site of disease in 9 patients, while 8 had concomitant extra-peritoneal dissemination. The median survival (MS) from diagnosis of cerebral metastases for the entire series was five months. Four patients were not treated (MS 3 months); 14 received radiotherapy (MS 5.5 months), and five underwent surgical resection of solitary metastases followed by radiotherapy (MS 17 months). Number of CNS lesions, extent of the disease at the time of CNS metastasis and treatment were the only factors which significantly affected survival.

CONCLUSIONS: The prognosis of patients with CNS metastasis from ovarian carcinoma appears poor. However, early diagnosis followed by multimodal treatment may result in significant palliation and improve overall survival in a selected group of patients.

central nervous system metastasis, ovarian carcinoma


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Cancer ResHome page
D. Belotti, C. Calcagno, A. Garofalo, D. Caronia, E. Riccardi, R. Giavazzi, and G. Taraboletti
Vascular Endothelial Growth Factor Stimulates Organ-Specific Host Matrix Metalloproteinase-9 Expression and Ovarian Cancer Invasion
Mol. Cancer Res., April 1, 2008; 6(4): 525 - 534.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
D. Pectasides, M. Pectasides, and T. Economopoulos
Brain metastases from epithelial ovarian cancer: a review of the literature.
Oncologist, March 1, 2006; 11(3): 252 - 260.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Atallah, G. Chahine, and I. A. Voutsadakis
Uncommon Presentations of Malignancies: CASE 3. BRAIN METASTASIS FROM OVARIAN CANCER
J. Clin. Oncol., August 1, 2003; 21(15): 2996 - 2998.
[Full Text] [PDF]

Home page
 JCOHome page
D. F. Kolomainen, J. M.G. Larkin, M. Badran, R. P. A'Hern, D. M. King, C. Fisher, J. E. Bridges, P. R. Blake, D. P.J. Barton, J. H. Shepherd, et al.
Epithelial Ovarian Cancer Metastasizing to the Brain: A Late Manifestation of the Disease With an Increasing Incidence
J. Clin. Oncol., February 15, 2002; 20(4): 982 - 986.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.