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Annals of Oncology 2009 20(Supplement 6):vi1-vi7; doi:10.1093/annonc/mdp252
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
The online version of this article has been published under an open access model. users are entitle to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and the European Society for Medical Oncology are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

This article appears in the following Annals of Oncology issue: Melanoma: Perspectives of the Global Melanoma Task Force [View the issue table of contents]

Articles

Epidemiology of invasive cutaneous melanoma

R. M. MacKie1,*, A. Hauschild2 and A. M. M. Eggermont3

1 Department of Public Health and Health Policy, University of Glasgow, UK
2 Department of Dermatology, University of Kiel, Kiel, Germany
3 Department of Surgical Oncology, Erasmus University Medical Centre–Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands

* Correspondence to: Rona M. MacKie, Department of Public Health and Health Policy, University of Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZ, UK; Tel: +44-141-330-5013; Fax: +44-141-330-5018; E-mail: R.M.Mackie{at}clinmed.gla.ac.uk

Data are presented on the current incidence of melanoma with recent and predicted future trends illustrating a likely continuing increase in incidence. Risk factors for developing melanoma are discussed, including current known melanoma susceptibility genes. Phenotypic markers of high-risk subjects include high counts of benign melanocytic naevi. Other risk factors considered include exposure to natural and artificial ultraviolet radiation, the effect of female sex hormones, socioeconomic status, occupation, exposure to pesticides and ingestion of therapeutic drugs including immunosuppressives and non-steroidal anti-inflammatory drugs. Aids to earlier diagnosis are considered, including public education, screening and use of equipment such as the dermatoscope. Finally, the current pattern of survival and mortality is described.

Key words: cutaneous melanoma, incidence, mortality, risk factors, survival


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