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Annals of Oncology Advance Access originally published online on March 17, 2009
Annals of Oncology 2009 20(7):1257-1263; doi:10.1093/annonc/mdn785
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

lung cancer

The NER proteins are differentially expressed in ever smokers and in never smokers with lung adenocarcinoma

D. Planchard1,2, J. Domont1, E. Taranchon2, I. Monnet3, J. Tredaniel4, R. Caliandro5, P. Validire6, B. Besse1, J.-C. Soria1,7 and P. Fouret2,8,*

1 Medical Oncology and Translational Research, Institut de Cancérologie Gustave Roussy,Villejuif
2 Medical Oncology, Institut de Cancérologie Gustave Roussy,Villejuif
3 Department of Pneumology Creteil, Intercommunal Hospital of Creteil, Creteil
4 Department of Pneumology, Saint-Louis Hospital, Paris
5 Department of Thoracic Disease, Institut Mutualiste Montsouris, Paris
6 Department of Pathology, Institut Mutualiste Montsouris, Paris
7 Department of Medical Oncology, Institut Gustave Roussy, Villejuif
8 Department of Pathology, Institut de Cancérologie Gustave Roussy,Villejuif, France

* Correspondence to: Dr P. Fouret, Department of Translational Research, Institut de Cancérologie Gustave Roussy, 94805 Villejuif Cedex, France. Tel: +33-142116510; Fax: +33-142116094; E-mail: pierre.fouret{at}igr.fr

Background: The expression levels of excision repair cross-complementation group 1 (ERCC1), replication protein A (RPA) and xeroderma pigmentosum group F (XPF) nucleotide excision repair proteins may be important in the response to platin-based therapy in lung cancer patients. It is not known whether ERCC1, RPA and XPF expression levels differ between ever smokers (ES) and never smokers (NS).

Patients and methods: ERCC1, RPA and XPF expression levels were immunohistochemically evaluated in 125 patients with resected lung adenocarcinoma (AC) and carefully reviewed smoking status.

Results: ERCC1 was correlated with XPF (P = 0.001), but not with RPA (P = 0.11). In the univariate analysis, ERCC1 and XPF levels were higher in NS compared with ES (P = 0.004 and P = 0.003, respectively). In the multivariate analysis, the smoking status was predictive of the ERCC1 level [odds ratio (OR) 2.5, 95% confidence interval (CI) 1.03–6.2] after adjustment for variables linked to the smoking status, including age and the presence of bronchioloalveolar (BAC) features. The smoking status was also predictive of both RPA (OR 6.7, 95% CI 1.5–33.3) and XPF levels (OR 12.5, 95% CI 2.9–50) after adjusting for age, sex and BAC features.

Conclusion: In patients with resected lung AC, ERCC1, RPA and XPF expression levels are higher in NS compared with ES.

Key words: ERCC1, immunohistochemistry, lung adenocarcinoma, NER, never smoker

Received for publication September 21, 2008. Revision received December 3, 2008. Accepted for publication December 5, 2008.


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