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Annals of Oncology Advance Access originally published online on January 29, 2009
Annals of Oncology 2009 20(6):1127-1135; doi:10.1093/annonc/mdn757
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Sarcomas and melanoma (da dividere nel caso i ms siano solo su un argomento)

Soft tissue sarcomas of the trunk wall (STS-TW): a study of 343 patients from the French Sarcoma Group (FSG) database

S. Salas1,*, B. Bui2, E. Stoeckle3, P. Terrier4, D. Ranchere-Vince5, F. Collin6, A. Leroux7, L. Guillou8, J. J. Michels9, M. Trassard10, I. Valo11, Y.-M. Robin12, B. Marques13, V. Brouste14 and J.-M. Coindre1,15

1 Department of Pathology
2 Department of Medicine
3 Department of Surgery, Bergonié Institute, Bordeaux
4 Department of Pathology, Gustave Roussy Institute, Villejuif
5 Department of Pathology, Leon Berard Center, Lyon
6 Department of Pathology, Georges-François Leclerc Center, Dijon
7 Department of Pathology, Alexis Vautrin Center, Nancy, France
8 Department of Pathology, University Institute of Pathology, Lausanne, Switzerland
9 Department of Pathology, François Baclesse Center, Caen
10 Department of Pathology, Rene Huguenin Center, Saint-Cloud
11 Department of Pathology, Paul Papin Center, Angers
12 Department of Pathology, Oscar Lambret Center, Lille
13 Department of Pathology, Claudius Regaud Center, Toulouse
14 Department of Biostatistics, Institut Bergonié, Bordeaux
15 University Victor Ségalen, Bordeaux, France

* Correspondence to: Dr S. Salas, Département de Pathologie, Institut Bergonié, 229, cours de l’Argonne, 33076 Bordeaux Cedex, France. Tel: +33-5-56-33-44-36; Fax: +33-5-56-33-04-38; E-mail: sebastien.salas{at}ap-hm.fr

Background: Soft tissue sarcomas of the trunk wall (STS-TW) are usually studied together with soft tissue sarcomas of other locations. We report a study on STS-TW forming part of the French Sarcoma Group database.

Patients and methods: Three hundred and forty-three adults were included. We carried out univariate and multivariate analysis for overall survival (OS), metastasis-free survival (MFS) and local recurrence-free survival (LRFS).

Results: Tumor locations were as follows: thoracic wall, 82.5%; abdominal wall, 12.3% and pelvic wall, 5.2%. Median tumor size was 6.0 cm. The most frequent tumor types were unclassified sarcoma (27.7%) and myogenic sarcoma (19.2%). A total of 44.6% of cases were grade 3. In all, 21.9% of patients had a previous medical history of radiotherapy (PHR). Median follow-up was 7.6 years. The 5-year OS, MFS and LRFS rates were 60.4%, 68.9% and 58.4%, respectively. Multivariate analysis retained PHR and grade for predicting LRFS and PHR, size and grade as prognostic factors of MFS. Factors influencing OS were age, size, PHR, depth, grade and surgical margins. The predictive factors of incomplete response were PHR, size and T3.

Conclusions: Our results suggest similar classical prognostic factors as compared with sarcomas of other locations. However, a separate analysis of STS-TW revealed a significant poor prognosis subgroup of patients with PHR.

Key words: predictive factors, prognostic factors, soft tissue sarcoma, trunk wall

Received for publication October 14, 2008. Revision received November 20, 2008. Accepted for publication November 24, 2008.


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