Skip Navigation


Annals of Oncology Advance Access originally published online on January 15, 2009
Annals of Oncology 2009 20(5):950-954; doi:10.1093/annonc/mdn706
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
20/5/950    most recent
mdn706v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hiripi, E.
Right arrow Articles by Hemminki, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hiripi, E.
Right arrow Articles by Hemminki, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

epidemiology

Familial gastrointestinal carcinoid tumours and associated cancers

E. Hiripi1,*, J. Lorenzo Bermejo1, J. Sundquist2 and K. Hemminki1,2

1 Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
2 Karolinska Institute, Center for Family and Community Medicine, Huddinge, Sweden

* Correspondence to: Ms. E. Hiripi, Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, Heidelberg 69120, Germany. Tel: +49-6221-421805; Fax: +49-6221-421810; E-mail: e.hiripi{at}dkfz-heidelberg.de

Background: Carcinoid tumours are neuroendocrine neoplasms mainly located in the gastrointestinal tract and bronchopulmonary system. Our study's aim was to characterise the familial nature of gastrointestinal carcinoid tumours using the Swedish Family-Cancer Database, which includes >11.5 million individuals.

Methods: Familial relative risks (RRs) of carcinoid tumours were estimated for individuals with family history of invasive cancers. RRs of invasive cancers for the offspring of patients with carcinoid tumours were calculated as well. RRs were based on Poisson regression.

Results: The risk of carcinoid tumours was significantly increased among individuals with a parental history of carcinoid tumours (RR 4.33). An association was also found between carcinoid tumours in the offspring and parental invasive cancers of the brain, breast, liver, endocrine glands and urinary organs. In addition, parental invasive cancers of the kidney as well as squamous cell skin cancer associated with small intestinal carcinoids in the offspring. The risk of carcinoid tumours was elevated among those whose siblings were affected by colon and rectal cancers.

Conclusion: The results describe the familial aggregation of carcinoid tumours with other noncarcinoid malignancies. Carcinoid tumours are rare and translating these results into screening programmes needs more research; however, gene finding studies should be stimulated.

Key words: carcinoid tumours, gastrointestinal tumours

Received for publication April 15, 2008. Revision received September 23, 2008. Accepted for publication October 10, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.