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Annals of Oncology Advance Access originally published online on December 12, 2008
Annals of Oncology 2009 20(3):526-533; doi:10.1093/annonc/mdn677
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© The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

hematologic malignancies

Soluble interleukin-2 receptor retains prognostic value in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP (RCHOP) therapy

D. Ennishi1,5, M. Yokoyama1, Y. Terui1, H. Asai1, S. Sakajiri1, Y. Mishima1, S. Takahashi1, H. Komatsu2, K. Ikeda3, K. Takeuchi4, M. Tanimoto5 and K. Hatake1,*

1 Department of Medical Oncology and Hematology, Cancer Institute Hospital, Tokyo
2 Department of Epidemiology
3 Department of Transfusion Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama
4 Devision of Pathology, The Japanese Foundation for Cancer Research, Tokyo
5 Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

* Correspondence to: Dr Kiyohiko Hatake, Department of Medical Oncology and Hematology, Cancer Institute Hospital, 3-10-6 Ariake Koto-ku, Tokyo 135-8550, Japan. Tel: +81-3-3520-0111; Fax: +81-3-3570-0343; E-mail: khatake{at}jfcr.or.jp

Background: Soluble interleukin-2 receptor (SIL-2R) is known to be a prognostic parameter in patients with diffuse large B-cell lymphoma (DLBCL) receiving cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) therapy. However, its prognostic value has not been well known since the introduction of rituximab.

Patients and methods: We retrospectively evaluated the prognostic impact of SIL-2R in 228 DLBCL patients, comparing 141 rituximab-combined CHOP (RCHOP)-treated patients with 87 CHOP-treated patients as a historical control.

Results: Patients with high serum SIL-2R showed significantly poorer event-free survival (EFS) and overall survival (OS) than patients with low SIL-2R in both the RCHOP group (2-year EFS, 66% versus 92%, P < 0.001; OS, 82% versus 95%, P = 0.005) and the CHOP group (2-year EFS, 40% versus 82%; OS, 61% versus 90%, both P < 0.001). Multivariate analysis including the five parameters of International Prognostic Index (IPI) and two-categorized IPI revealed that SIL-2R was an independent prognostic factor for EFS and OS in the RCHOP group as well as in the CHOP group.

Conclusions: Our results demonstrate that SIL-2R retains its prognostic value in the rituximab era. The prognostic value of SIL-2R in DLBCL patients receiving rituximab-combined chemotherapy should be reassessed on a larger scale and by long-term follow-up.

Key words: diffuse large B-cell lymphoma, rituximab, soluble interleukin-2 receptor

Received for publication July 5, 2008. Revision received September 11, 2008. Accepted for publication September 16, 2008.


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