Skip Navigation


Annals of Oncology Advance Access originally published online on August 22, 2008
Annals of Oncology 2009 20(2):353-357; doi:10.1093/annonc/mdn565
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
20/2/353    most recent
mdn565v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Polesel, J.
Right arrow Articles by Talamini, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Polesel, J.
Right arrow Articles by Talamini, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

epidemiology

The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma

J. Polesel1,*, A. Zucchetto1, M. Montella2, L. Dal Maso1, A. Crispo2, C. La Vecchia3,4, D. Serraino1, S. Franceschi5 and R. Talamini1

1 S.O.C. Epidemiologia e Biostatistica, IRCCS, Centro di Riferimento Oncologico, Aviano
2 Epidemiology Service, Istituto Tumori "Fondazione Pascale," Naples
3 Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri"
4 Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy
5 International Agency for Research on Cancer, Lyon, France

* Correspondence to: Dr J. Polesel, S.O.C., Epidemiologia e Biostatistica, IRCCS, Centro di Riferimento Oncologico, Via Franco Gallini 2, 33081 Aviano, Pordenone, Italy. Tel: +39-0434-659354; Fax: +39-0434-659231; E-mail: polesel{at}cro.it

Background: Obesity has been associated to increased hepatocellular carcinoma (HCC) risk, but studies on the topic do not fully account for hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Likewise, an increased risk has been reported for diabetes mellitus (DM) but whether DM is an independent risk factor has not been established yet. To evaluate the association of obesity and DM with HCC risk, we conducted a hospital-based, case–control study in two Italian areas.

Patients and methods: From 1999 to 2003, 185 HCC cases and 404 hospital controls were enrolled. Blood samples were obtained for HBV and HCV screening.

Results: After allowance for known risk factors, body mass index ≥30 kg/m2 [odds ratio (OR) = 1.9, 95% confidence interval (CI) 0.9–3.9] and DM (OR = 3.7, 95% CI 1.7–8.4) were associated to HCC risk. These associations persisted (OR = 3.5, 95% CI 1.6–7.7 for obesity; OR = 3.5, 95% CI 1.3–9.2 for DM) among subjects without HBV and/or HCV infection. Overall, 23% of HCC cases seemed attributable to these conditions, and this figure rose to 37% among subjects without HBV and/or HCV infections.

Conclusions: The present study provides further evidence that obesity and DM increase HCC risk and that these factors may explain a relevant proportion of cases among subjects without markers of HBV/HCV infection.

Key words: attributable risk, diabetes mellitus, HBV, HCV, hepatocellular carcinoma, obesity

Received for publication April 29, 2008. Accepted for publication July 18, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann OncolHome page
M. Rossi, L. Lipworth, L. D. Maso, R. Talamini, M. Montella, J. Polesel, J. K. McLaughlin, M. Parpinel, S. Franceschi, P. Lagiou, et al.
Dietary glycemic load and hepatocellular carcinoma with or without chronic hepatitis infection
Ann. Onc., October 1, 2009; 20(10): 1736 - 1740.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.