Annals of Oncology Advance Access originally published online on July 16, 2009
Annals of Oncology 2009 20(11):1771-1785; doi:10.1093/annonc/mdp261
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Third consensus on medical treatment of metastatic breast cancer
1 Institute of Oncology, Sarajevo, Bosnia and Herzegovina
2 Centre Oscar Lambret, Lille, France
3 Dana-Farber Cancer Institute, Boston, MA, USA
4 Oncologisch Centrum, Universitair Ziekenhuis, Gent, Belgium
5 Department of Surgery, Medical University of Vienna, Vienna, Austria
6 Medizinische Klinik und Poliklinik III Klinikum Großhadern, Munich, Germany
7 Department of Oncology and Radiotherapy, Medical University, Gdansk, Poland
8 Clinical Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
9 Istituto Tumori, Milan, Italy
10 Centre Paul Strauss, Strasbourg, France
11 Department of Oncology, Charles University, Prague, Czech Republic
12 Medizinische Klinik der Charite, Berlin, Germany
13 Charing Cross Hospital, Imperial College, London, UK
14 University of Pennsylvania Cancer Center, Philadelphia, PA, USA
15 Sydney Cancer Centre, Royal Prince Alfred Hospital and Concord Hospitals, University of Sydney, Camperdown, Sydney, New South Wales, Australia
16 Breast Cancer for Aptium Oncology at Lynn Cancer Institute-West, Boca Raton, FL, USA
17 Department of Medical Oncology and Palliative Care, Westmead Hospital, Sydney, Australia
18 Central European Cooperative Oncology Group, Vienna, Austria
19 Department of Medicine l, Medical University of Innsbruck, Austria
* Correspondence to: Prof. C. C. Zielinski, Clinical Division of Oncology, Department of Medicine I, General Hospital, Medical University of Vienna, 18–20 Waehringer Guertel, A-1090 Vienna, Austria. Tel: +43-1-40400-4445; Fax: +43-1-40400-4428; E-mail: christoph.zielinski{at}meduniwien.ac.at
Background: Treatment options for patients with metastatic breast cancer (MBC) include a rapidly expanding repertoire of medical, surgical and supportive care measures.
Design: To provide timely and evidence-based recommendations for the diagnostic workup and treatment of patients with MBC, an international expert panel reviewed and discussed the evidence available from clinical trials regarding diagnostic, therapeutic and supportive measures with emphasis on their impact on the quality of life and overall survival of patients with MBC.
Results: Evidence-based recommendations for the diagnostic workup, endocrine therapy, chemotherapy, use of targeted therapies and bisphosphonates, surgical treatment and supportive care measures in the management of patients with MBC were formulated.
Conclusions: The present consensus manuscript updates evidence-based recommendations for state-of-the-art treatment of MBC depending on disease-associated and biological variables.
Key words: diagnosis, metastatic breast cancer, prognosis, treatment
Received for publication February 17, 2009. Revision received March 23, 2009. Accepted for publication March 30, 2009.