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Annals of Oncology 2:597-603, 1991
© 1991 European Society for Medical Oncology

research-article

Original article: On the receiving end IV: Validation of quality of life indicators

P. Butow1, A. Coates2, S. Dunn1, J. Bernhard3 and C. Hürny4

1Department of Medicine, University of Sydney NSW, Australia
2Department of Cancer Medicine, University of Sydney NSW, Australia
3Swiss group for Epidemiological and Clinical Cancer Research (SAKK) Bern
4Medical Division Lory, Inselspital Bern, Switzerland

Correspondence to: Phyllis Bulow, Ph.D., Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia

Four measures of patient functioning and a mood adjective list currently used in trials of the International Breast Cancer Study Group (IBCSG), and an 8-item Linear Analogue Self Assessment (LASA) instrument measuring specific side effects of cancer and cancer treatment (GLQ-8), were cross-validated against three established measures of quality of life, mood and psychological adjustment to cancer, in a heterogeneous sample of cancer patients. Correlations between new and established measures were high, indicating good convergent and concurrent validity. Compliance on the longer mood measures was relatively poor. Despite the difficulty in developing direct and methodologically sound measures of quality of life, the regular inclusion of practical indicators of aspects of quality of life in clinical trials would allow improved assessment of the cost-benfit ratio of treatment to outcome in cancer patients.

clinical trials, psychological adjustment, quality of life, validation


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