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Annals of Oncology 2:585-587, 1991
© 1991 European Society for Medical Oncology

research-article

Original article: Non-Hodgkin's lymphoma after prolonged remission of Hodgkin's disease in an HTV-infected patient

C. Montalban1, C. Bellas2, J. L. Rodriguez-Garcia1, M. Aguado1 and R. Fernandez-Munoz3

1Departments of Internal Medicine, Hospital Ramon y Cajal Madrid, Spain
2Departments of Pathology, Hospital Ramon y Cajal Madrid, Spain
3Departments of Virology Hospital Ramon y Cajal Madrid, Spain

Correspondence to: Dr. C. Montalban, Servicio de Medicina Interna, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 28034 Madrid, Spain

Hodgkin's disease was diagnosed in a 22-year-old HTV-seropositive man in 1986. Alternate MOPP/ ABVD chemotherapy induced a clinical remission. He was asymptomatic until 3 years later when fever and peripheral and mediastinal lymphadenopathy appeared. Lymph node biopsy showed a large-cell anaplastic lymphoma and EBV genome was identified in the malignant cells, suggesting that transformation might had been induced by EBV. The present case affirms that in patients with HIV-related lymphomas who present enlarging lymphadenopathy after stable remission, the development of lymphomas of higher malignancy needs to be ruled out.

HIV-related lymphomas, Hodgkin's, Non-Hodgkin's lymphoma


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