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Annals of Oncology 2:213-215, 1991
© 1991 European Society for Medical Oncology

research-article

Original article: Intrapleural palliative treatment of malignant pleural effusions with mitoxantrone versus placebo (pleural tube alone)

G. Groth1, U. Gatzemeier1, K. HäuBingen2, M. Heckmayr1, H. Magnussen1, R. Neuhauss1 and J. V. Pavel2

1Department of Thoracic Oncology, Hospital Grosshansdorf Hamburg
2Department of Pneumology, Hospital Gauting Muenchen, Germany

Correspondence to: Dr.med. U. Gatzemeier, Department of Thoracic Oncology, Hospital Grosshansdorf, Woehrendamm 80, 2070 Grosshansdorf, Germany

From 11/87 until 7/90 103 patients entered a prospective randomized trial on the treatment of malignant pleural effusions (MPE) with intrapleural mitoxantrone versus placebo (pleural tube alone with instillation of isotonic NaCl). Our data suggest no statistically significant difference between the two arms with respect to response and response duration. There is no influence on survival time. The toxicity is moderate, with only fever occurring more often in the mitoxantrone arm. We recommend performance of pleurodesis in patients with MPE first by sufficient drainage with a tube of 16–20 char. Only in instances of failure it is necessary to add sclerosing agents such as tetracycline, etc.

malignant pleural effusion, intrapleural treatment, mitoxantrone, placebo


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