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Annals of Oncology 2:767-768, 1991
© 1991 European Society for Medical Oncology

other

Short report: Phase II study of ACNU as first-line treatment in advanced colorectal cancer

A. Planting, A. Hoff, M. van der Burg, J. Verweij and G. Stoter

Department of Medical Oncology, Rotterdam Cancer Center Dr. Daniel den Hoed Kliniek Rotterdam, The Netherlands

Correspondence to: A. Planting, M.D. Department of Medical Oncology Rotterdam Cancer Center/Dr. Daniel den Hoed Kliniek P.O. Box 3201 3008 AE Rotterdam The Netherlands

Thirty-two patients with metastatic colorectal cancer were entered in a phase II study of ACNU as first-line treatment. ACNU was given at a dose of 100 mg/m2 i.v. every six weeks. In 30 evaluable patients we observed partial responses lasting 5 and 8 months in 2 patients with liver metastases, and stable disease in 4 patients. The toxicity mainly consisted of leuco- and trombocytopenia. We conclude that in this dose and schedule ACNU has only very limited activity in metastatic colorectal cancer.

phase II, colorectal cancer, ACNU


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