Skip Navigation


Annals of Oncology Advance Access originally published online on January 22, 2008
Annals of Oncology 2008 19(5):996-1002; doi:10.1093/annonc/mdm578
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
19/5/996    most recent
mdm578v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Ann Oncol
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Batty, G. D.
Right arrow Articles by Shipley, M. J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Batty, G. D.
Right arrow Articles by Shipley, M. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

epidemiology

Cigarette smoking and site-specific cancer mortality: testing uncertain associations using extended follow-up of the original Whitehall study

G. D. Batty1,*, M. Kivimaki2, L. Gray1, G. Davey Smith3, M. G. Marmot2 and M. J. Shipley2

1 Medical Research Council Social and Public Health Sciences Unit, University of Glasgow, Glasgow
2 Department of Epidemiology and Public Health, University College London, London
3 Department of Social Medicine, University of Bristol, Bristol, UK

* Correspondence to: Dr G. D. Batty, Medical Research Council Social and Public Health Sciences Unit, University of Glasgow, 4 Lilybank Gardens, Glasgow G12 8RZ, UK. Tel: +44-141-357-7520; Fax: +44-141-337-2389; E-mail: david-b{at}msoc.mrc.gla.ac.uk

Background: The relation between cigarette smoking and several malignancies is still unclear. We examined the association of cigarette smoking with death attributed to 15 cancer sites, 7 of which are regarded as having an uncertain relation with tobacco.

Patients and methods: The original Whitehall study is a prospective cohort of 17 363 London-based male government employees (age 40–69 years) who were examined in the late 1960s and then followed up for a maximum of 38 years.

Results: Following adjustment for demographic characteristics, risk factors, and prevalent disease, established positive cigarette smoking—cancer gradients were confirmed for carcinoma of the lung, stomach, pancreas, bladder, upper aero-digestive (including oesophagus), and liver, and for myeloid leukaemia. Among the cancers of uncertain relation with smoking, mortality rates for malignancy of the colon, rectum and prostate and for lymphatic leukaemia were elevated in current and/or former smokers. There was essentially no apparent relation between smoking and mortality from carcinoma of the brain or from lymphoma.

Conclusion: In this study, cigarette smoking appears to be a risk factor for several malignancies of previously unclear association with tobacco use.

Key words: cancer, cigarette smoking, cohort study, Whitehall

Received for publication November 14, 2007. Revision received November 27, 2007. Accepted for publication November 29, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in Ann Oncol:

In this issue

Ann Oncol 2008 19: 827. [Extract] [Full Text]  





Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.