Skip Navigation


Annals of Oncology Advance Access originally published online on November 12, 2007
Annals of Oncology 2008 19(2):269-275; doi:10.1093/annonc/mdm490
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
19/2/269    most recent
mdm490v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Domingo-Domenech, J.
Right arrow Articles by Mellado, B.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Domingo-Domenech, J.
Right arrow Articles by Mellado, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 European Society for Medical Oncology. For Permissions, please email: journals.permissions@oxfordjournals.org

urogenital tumors

Serum HER2 extracellular domain predicts an aggressive clinical outcome and biological PSA response in hormone-independent prostate cancer patients treated with docetaxel

J. Domingo-Domenech1, P. L. Fernandez2, X. Filella3, A. Martinez-Fernandez1, R. Molina3, E. Fernandez2, A. Alcaraz4, J. Codony1, P. Gascon1 and B. Mellado1,*

1 Department of Medical Oncology and Laboratory of Experimental Oncology, Institut Clínic de Malalties Hemato-Oncològiques
2 Department of Pathology
3 Department of Biochemistry, Centre Diagnostic Biomèdic
4 Department of Urology, Institut d' Investigacions Biomèdiques Agust Pi i Sunyer, University of Barcelona, Hospital Clinic, Barcelona, Spain

* Correspondence to: Dr B. Mellado, Hospital Clinic i Provincial—Medical Oncology Villarroel, 130 Barcelona 08901, Spain. Tel: +34-932275400 Fax: +34-934546520; E-mail: bmellado{at}clinic.ub.es

Background: Human epidermal growth factor receptor 2 (HER2) overexpression has been linked to hormone-independent prostate cancer (HIPC) progression. Its clinical value and correlation with therapy is not defined.

Patients and methods: Patients with HIPC treated with docetaxel (Taxotere) were prospectively tested for serum HER2 extracellular domain (ECD) by immunoanalysis. HER2 was determined by immunohistochemistry and fluorescence in situ hybridization (FISH) in tumor samples.

Results: Sixty-nine patients were included. Twenty-four (34.8%) patients had high HER2 ECD (>15 ng/ml). Prostate-specific antigen (PSA) response was 58% for patients with low HER2 ECD and 36% for patients with high HER2 ECD (P = 0.046). HER2 ECD levels were an independent prognostic factor for time to PSA progression [hazard ratio (HR) 2.82; 95% confidence interval (CI) 1.22–6.50; P = 0.015] and overall survival (HR 3.24; 95% CI 1.38–7.59; P = 0.007). Tissue samples from 17 patients were tested for HER2. Patients with negative HER2 tissue expression had lower HER2 ECD levels (median 10.5 ± 2.7 versus 30.5 ± 24.8 ng/ml; P = 0.016). FISH was negative in all samples.

Conclusions: High HER2 ECD levels in serum are associated with a worst clinical outcome of HIPC patients treated with docetaxel.

Key words: docetaxel, HER2, HER2 ECD, hormone-independent prostate cancer

Received for publication June 27, 2007. Revision received August 18, 2007. Accepted for publication September 18, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.