Annals of Oncology Advance Access originally published online on July 17, 2008
Annals of Oncology 2008 19(12):2001-2006; doi:10.1093/annonc/mdn421
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breast cancer |
The clinical significance of radiologically detected silent pulmonary nodules in early breast cancer
1 Department of Medical Oncology
2 Department of Radiology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London
3 Department of Respiratory Medicine, Imperial College Healthcare NHS Trust, Charing Cross Hospital, St Mary's Hospital, London
4 Department of Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK
* Correspondence to: Dr J Stebbing, Department of Medical Oncology, Imperial college, The Hammersmith Hospitals NHS Trust, Charing Cross Hospital, First Floor, E Wing, Fulham Palace Road, London W6 8RF, UK. Tel: +44-208-7468295; Fax: +44-208-8461433; E-mail: j.stebbing{at}imperial.ac.uk
Background: Increasing numbers of patients with early cancer undergo routine staging using computerized tomography (CT). Those in whom indeterminate pulmonary nodules are visualized without the presence of other metastatic lesions represent a clinical dilemma regarding their management as early breast cancer or metastatic disease.
Patients and methods: Medical records of breast cancer patients who underwent thoracic CT scans between the years 2002 and 2008 were analyzed. Those with obvious metastatic disease were excluded. Patients were identified via the radiology database by searching for the terms: ‘suspicious lung metastases’ and ‘indeterminate nodules’.
Results: Out of 1578 new patients assessed from 2002 to 2008, we carried out 802 staging CT scans. Thirty-four cases (4.2%) with indeterminate pulmonary nodules were identified. We categorized cases by size and number of nodules. At a median follow-up of 18 months, there were no changes in lesion size in 86% of patients with a solitary nodule <1 cm and 89% with multiple subcentimeter nodules. In contrast, in 100% of cases with pulmonary nodules >1 cm, the nodules had progressed at follow-up (
2, P = 0.004).
Conclusions: Breast cancer cases with subcentimeter indeterminate pulmonary lesions and no evidence of metastases elsewhere are unlikely to represent metastatic disease. Treatment with curative intent or entry into clinical trials should not be excluded.
Key words: breast cancer, CT, indeterminate, lung nodule, suspicious
Received for publication May 28, 2008. Accepted for publication June 10, 2008.