Skip Navigation


Annals of Oncology Advance Access originally published online on September 24, 2007
Annals of Oncology 2008 19(1):168-172; doi:10.1093/annonc/mdm446
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
19/1/168    most recent
mdm446v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lucenteforte, E.
Right arrow Articles by Negri, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lucenteforte, E.
Right arrow Articles by Negri, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 European Society for Medical Oncology. For Permissions, please email: journals.permissions@oxfordjournals.org

epidemiology

Macronutrients, fatty acids and cholesterol intake and endometrial cancer

E. Lucenteforte1,*, R. Talamini2, M. Montella3, L. Dal Maso2, A. Tavani1, S. Deandrea1,4, C. Pelucchi1, S. Greggi5, A. Zucchetto2, F. Barbone6, M. Parpinel6, S. Franceschi7, C. La Vecchia1,8 and E. Negri1

1 Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan
2 Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano
3 Unità di Epidemiologia, Istituto Nazionale Tumori ‘Fondazione Giovanni Pascale’, Naples
4 Scuola di Specializzazione in Igiene e Medicina Preventiva, Università degli Studi di Pavia, Pavia
5 Unità operativa di ginecologia, Istituto Nazionale Tumori ‘Fondazione Giovanni Pascale’, Naples
6 Istituto di Igiene ed Epidemiologia, Dipartimento di Patologia e Medicina Sperimentale e Clinica, Università degli studi di Udine, Udine, Italy
7 International Agency for Research on Cancer, Lyon Cedex, France
8 Istituto di Statistica Medica e Biometria ‘G. A. Maccacaro’, Università degli Studi di Milano, Milan, Italy

* Correspondence to: Dr E. Lucenteforte, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via La Masa 19, 20156 Milan, Italy. Tel: +39-02-39014652; Fax: +39-02-33200231; E-mail: lucenteforte{at}marionegri.it

Background: There is some evidence that dietary habits may influence the risk of endometrial cancer independently of body mass, although the role of diet on endometrial carcinogenesis is unclear.

Patients and methods: We carried out a multicenter case–control study from 1992 to 2006 in Italy on 454 women with incident, histologically confirmed endometrial cancer (age range 18–79 years) and 908 controls (age range 19–79 years) admitted to hospitals for acute, non-neoplastic diseases. A validated food-frequency questionnaire was used to estimate macronutrients, fatty acids and cholesterol intake. Logistic regression models, conditioned on age and study centre, and adjusted for major known risk factor of endometrial cancer and residual of energy intake were used to estimate odds ratios (OR) and 95% confidence intervals (CI).

Results: Significant direct associations were observed with intake of energy (OR = 1.7 for the highest versus the lowest quintile, 95% CI = 1.1–2.5), and cholesterol (OR = 2.1, 95% CI = 1.4–3.2), while a direct borderline association emerged with saturated fatty acids (OR = 1.3, 95% CI = 0.9–2.0). There was no association with proteins, sugars, starch, total fat and other selected fatty acids.

Conclusion: Energy and cholesterol intake were associated with endometrial cancer.

Key words: case–control study, cholesterol, endometrial cancer, energy, macronutrients

Received for publication April 13, 2007. Revision received July 24, 2007. Accepted for publication August 13, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.