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Annals of Oncology 2007 18(Supplement 6):vi133-vi135; doi:10.1093/annonc/mdm242
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© 2007 European Society for Medical Oncology

gastro-intestinal cancer

Chemoradiotherapy as adjuvant treatment of gastric cancer

M Orditura1,*, E Martinelli1, G Galizia2, F Vitiello1, M Fasano1, P Muto3, F Ciardiello1 and F De Vita1

1 Department of Medical Oncology
2 Department of Surgical Oncology, F. Magrassi & A. Lanzara, Second University of Naples School of Medicine, Naples
3 Division of Radiation Therapy ‘Ascalesi’ Hospital, Naples, Italy

* Correspondence to: M. Orditura, Department F. Magrassi & A. Lanzara, Second University of Naples School of Medicine, II Policlinico, via S. Pansini, 5, 80131 Naples, Italy. Tel/Fax: +39-081642948; E-mail: michele.orditura{at}unina2.it

Historically, radiotherapy has been occasionally used in the treatment of gastric cancer. More recently, the results of INT-0116 trial have shown an improvement of disease-free and overall survival by chemoradiation with a significant impact on the management of this tumor. Based on these data, there has been an increasing interest in radiotherapy and its association with chemotherapy for patients with locoregional disease as a part of an adjuvant treatment after surgery in high-risk patients. However, many questions remain to evaluate; first of all the toxicity of this approach and its efficacy after adequate surgery.


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