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Annals of Oncology Advance Access originally published online on March 12, 2007
Annals of Oncology 2007 18(9):1437-1449; doi:10.1093/annonc/mdm056
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© 2007 European Society for Medical Oncology

review

Prevalence of pain in patients with cancer: a systematic review of the past 40 years

MHJ van den Beuken-van Everdingen1,*, JM de Rijke1, AG Kessels2, HC Schouten3, M van Kleef4 and J Patijn1

1 Pain Management and Research Centre, University Hospital Maastricht
2 Department of Clinical Epidemiology and Medical Technology Assessment, University Hospital Maastricht
3 Department of Internal Medicine, University Hospital Maastricht
4 Department of Anaesthesiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands

* Correspondence to: Dr M. H. J. van den Beuken-van Everdingen, University Hospital Maastricht, Pain Management and Research Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands. Tel: +31-433875384; Fax: +31-433875457; E-mail: mvdb{at}adcc.azm.nl

Background: Despite the abundant literature on this topic, accurate prevalence estimates of pain in cancer patients are not available. We investigated the prevalence of pain in cancer patients according to the different disease stages and types of cancer.

Patients and methods: A systematic review of the literature was conducted. An instrument especially designed for judging prevalence studies on their methodological quality was used. Methodologically acceptable articles were used in the meta-analyses.

Results: Fifty-two studies were used in the meta-analysis. Pooled prevalence rates of pain were calculated for four subgroups: (i) studies including patients after curative treatment, 33% [95% confidence interval (CI) 21% to 46%]; (ii) studies including patients under anticancer treatment: 59% (CI 44% to 73%); (iii) studies including patients characterised as advanced/metastatic/terminal disease, 64% (CI 58% to 69%) and (iii) studies including patients at all disease stages, 53% (CI 43% to 63%). Of the patients with pain more than one-third graded their pain as moderate or severe. Pooled prevalence of pain was >50% in all cancer types with the highest prevalence in head/neck cancer patients (70%; 95% CI 51% to 88%).

Conclusion: Despite the clear World Health Organisation recommendations, cancer pain still is a major problem.

Key words: cancer pain, prevalence, systematic review

Received for publication December 18, 2006. Revision received January 11, 2007. Accepted for publication January 12, 2007.


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