© 2007 European Society for Medical Oncology
hematologic malignancies |
Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type
1 Department of Internal Medicine
2 Department of Pathology
3 Department of Diagnostic Radiology, Korea University Medical Center, Seoul, Korea
* Correspondence to: Dr B. S. Kim, Division of Oncology and Hematology, Department of Internal Medicine, Korea University Anam Hospital 126-1, Anamdong 5-ga, Seongbuk-ku, Seoul, 136-705, Korea. Tel: +82-2-920-5488; Fax: +82-2-920-6520; E-mail: kbs0309{at}korea.ac.kr
Background: Localized extranodal natural killer (NK)/T-cell lymphoma, nasal type, commonly has a low or low–intermediate risk of the international prognostic index (IPI), so the IPI has shown inconsistency in predicting prognosis. Thus, we analyzed Ki-67 expression and proposed a new prognostic model including Ki-67 expression for stage I/II extranodal NK/T-cell lymphoma.
Patients and methods: We studied Ki-67 expression and its relationship with prognosis in 50 patients with extranodal NK/T-cell lymphoma.
Results: The patients were dichotomized by the median value: low (<65%) versus high Ki-67 (
65%). High Ki-67 was associated with a worse overall survival (OS; P = 0.021) and disease-free survival (DFS; P = 0.044). In multivariate analysis, Ki-67 expression and primary site of involvement were found to be an independent prognostic factor for OS and DFS (P < 0.05). Based on these results, we proposed a new clinico-pathological prognostic model with Ki-67 expression and the primary site of involvement. It showed a high degree of correlation with worse OS and DFS (P < 0.001).
Conclusions: Ki-67 expression is predictive of prognosis, and our prognostic model may become a useful tool for predicting prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type.
Key words: NK/T cell, extranodal lymphoma, Ki-67, prognosis
Received for publication January 9, 2007. Revision received March 26, 2007. Accepted for publication March 30, 2007.
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