Skip Navigation

Annals of Oncology 2007 18(8):1382-1387; doi:10.1093/annonc/mdm183
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kim, S.
Right arrow Articles by Kim, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, S.
Right arrow Articles by Kim, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 European Society for Medical Oncology

hematologic malignancies

Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type

SJ Kim1, BS Kim1,*, CW Choi1, J Choi2, I Kim2, Y-H Lee3 and JS Kim1

1 Department of Internal Medicine
2 Department of Pathology
3 Department of Diagnostic Radiology, Korea University Medical Center, Seoul, Korea

* Correspondence to: Dr B. S. Kim, Division of Oncology and Hematology, Department of Internal Medicine, Korea University Anam Hospital 126-1, Anamdong 5-ga, Seongbuk-ku, Seoul, 136-705, Korea. Tel: +82-2-920-5488; Fax: +82-2-920-6520; E-mail: kbs0309{at}korea.ac.kr

Background: Localized extranodal natural killer (NK)/T-cell lymphoma, nasal type, commonly has a low or low–intermediate risk of the international prognostic index (IPI), so the IPI has shown inconsistency in predicting prognosis. Thus, we analyzed Ki-67 expression and proposed a new prognostic model including Ki-67 expression for stage I/II extranodal NK/T-cell lymphoma.

Patients and methods: We studied Ki-67 expression and its relationship with prognosis in 50 patients with extranodal NK/T-cell lymphoma.

Results: The patients were dichotomized by the median value: low (<65%) versus high Ki-67 (≥65%). High Ki-67 was associated with a worse overall survival (OS; P = 0.021) and disease-free survival (DFS; P = 0.044). In multivariate analysis, Ki-67 expression and primary site of involvement were found to be an independent prognostic factor for OS and DFS (P < 0.05). Based on these results, we proposed a new clinico-pathological prognostic model with Ki-67 expression and the primary site of involvement. It showed a high degree of correlation with worse OS and DFS (P < 0.001).

Conclusions: Ki-67 expression is predictive of prognosis, and our prognostic model may become a useful tool for predicting prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type.

Key words: NK/T cell, extranodal lymphoma, Ki-67, prognosis

Received for publication January 9, 2007. Revision received March 26, 2007. Accepted for publication March 30, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.