Annals of Oncology Advance Access originally published online on March 9, 2007
Annals of Oncology 2007 18(5):898-902; doi:10.1093/annonc/mdm004
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© 2007 European Society for Medical Oncology
gastrointestinal tumors |
Paclitaxel given by a weekly 1-h infusion in advanced esophageal cancer
1 Memorial Sloan-Kettering Cancer Center, New York, NY
2 Veterans Affairs Medical Center, Washington DC
3 Roswell Park Cancer Institute, Buffalo, NY, USA
* Correspondence to: Dr D. H. Ilson, 1275 York Avenue, New York, NY 10021, USA. Tel: +1-212-639-8306; Fax: +1-212-717-3320; E-mail: ilsond{at}mskcc.org
Background: The purpose of the study was to evaluate the efficacy of weekly paclitaxel (Taxol) in advanced esophageal cancer.
Patients and methods: One hundred and two patients with advanced esophageal cancer were treated with paclitaxel 80 mg/m2 weekly over a 1-h infusion. One cycle was defined as 4 weeks of therapy. Ninety-five patients were assessable for toxicity and 86 patients who completed at least two cycles of treatment were assessable for response. Sixty-six patients had adenocarcinoma (66%) and 65 patients (68%) had no prior chemotherapy.
Results: A median of three cycles was delivered (range 1–11). Partial responses (PRs) were seen in 11 patients [13%, 95% confidence interval (CI) 6% to 20%]. In patients without prior chemotherapy, PRs were seen in 10 patients (15%, 95% CI 6% to 24%), with comparable response in adenocarcinoma (8/50, 16%) and squamous carcinoma (2/15, 13%). Limited response was seen in patients with prior chemotherapy (1/21, 5%). The median duration of response was 172 days. The median survival was 274 days. Therapy was well tolerated with minimal hematologic or grade 3 or 4 toxicity.
Conclusion: Weekly paclitaxel has limited activity in esophageal cancer. The median survival, modest activity, and tolerance of therapy indicate that weekly paclitaxel may be an option in patients unable to tolerate combination chemotherapy.
Key words: adenocarcinoma, esophageal cancer, squamous cell carcinoma, weekly paclitaxel
Current address: Eisenhower Medical Center, Rancho Mirage, CA, USA Received for publication September 26, 2006. Revision received January 8, 2007. Accepted for publication January 9, 2007.
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