Annals of Oncology Advance Access originally published online on October 30, 2006
Annals of Oncology 2007 18(2):311-316; doi:10.1093/annonc/mdl394
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© 2006 European Society for Medical Oncology
gastrointestinal tumors |
Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer
1 The Medical School of Da Tong University, Shanxi Medical University, Taiyuan
2 Department of Clinical Laboratory, Peking University School of Oncology, Beijing Cancer Hospital and Institute
3 Department of Cell Biology, The School of Basic Medical Sciences, Peking University, Beijing, China
* Correspondence to: Dr Q.-Y. Zhang, Department of Clinical Laboratory, Peking University School of Oncology, Beijing Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, 100036 Beijing, China. Tel: +86-010-88196336; E-mail: zhqy_208{at}163.com
Background: A novel gene called LAPTM4B (lysosome-associated protein transmembrane 4ß) was mapped to 8q22, and contains seven exons. The 2.25-kb messenger RNA of the gene encodes a putative lysosome-associated protein with four transmembrane regions. There are two alleles of the gene, named as LAPTM4B*1 and LAPTM4B*2. Allele *1 differs from allele *2 in that it contains only one copy of a 19-bp sequence in the 5' untranslated region (UTR), whereas this sequence is duplicated and tandemly arranged in allele *2. Studies showed that the allelic variation of LAPTM4B was associated with the genetic susceptibility of hepatocellular carcinoma but not with that of esophageal squamous cell carcinoma. This study was designed to investigate the possible association between the allelic variation of LAPTM4B and the genetic susceptibility of gastric cancer.
Materials and methods: The genotype of LAPTM4B was analyzed in 350 unrelated healthy adult individuals and 214 patients with gastric cancer by utilizing polymerase chain reaction based on specific primers. The genotypic distribution of LAPTM4B was analyzed by 
2 test.
Results: The allelic frequencies of the *2 were 33.88% and 24.14% in the gastric cancer group and the healthy control group, respectively, which was significantly different between the two groups (P < 0.001). There was a significant difference in the overall genotypic distribution between the patients and the controls (P = 0.023). The risk of suffering from gastric cancer was increased 1.819 times in the individuals of the *1/2 genotype [95% confidence interval (CI) 1.273–2.601] and 2.387 times in the individuals of the *2/2 genotype of LAPTM4B (95% CI 1.195–4.767) compared with the *1/1 genotype. No association between the genotypic distribution of LAPTM4B and the clinical information on patients of gastric cancer such as age, pathological type, differentiation classification of TNM, and infection of hepatitis B virus was shown.
Conclusion: This study indicated that allele *2 of LAPTM4B might be the risk factor of gastric cancer, which could be associated with genetic susceptibility of gastric cancer.
Key words: gastric cancer, gene polymorphism, LAPTM4B, susceptibility
Received for publication February 2, 2006. Revision received September 13, 2006. Accepted for publication September 14, 2006.
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