Annals of Oncology Advance Access originally published online on August 21, 2007
Annals of Oncology 2007 18(11):1817-1827; doi:10.1093/annonc/mdm337
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© 2007 European Society for Medical Oncology
urogential tumors |
The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma
1 Department of Urology
2 Department of Laboratory Medicine, Graduate School of Medicine, Yamaguchi University, Ube, Japan
* Correspondence to: Professor Katsusuke Naito, Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. Tel: +81-836-22-2275; Fax: +81-836-22-2276; E-mail: katsunai{at}yamaguchi-u.ac.jp
Background: DNA repair enzymes repair some of the DNA damage associated with risk factors for renal cell carcinoma (RCC), including smoking. DNA repair gene polymorphisms modulate the repair capacity and might influence individual risk and progression of RCC. We examined associations between functional polymorphisms and risk, clinicopathologic characteristics and survival of RCC.
Patients and methods: The study groups comprised 215 RCC patients and 215 age- and gender-matched healthy controls. Polymorphisms in xeroderma pigmentosum complementation groups C, D and G and X-ray repair cross-complementing groups 1 and 3 genes were genotyped.
Results: No significant differences in DNA repair genotype were observed between RCC cases and controls. In all patients, however, greater numbers (
3) of total variant alleles in all DNA repair genes studied were associated with less frequent venous extension (P = 0.0079). In smokers, some genotypes were associated with characteristics of RCC (Ps 
0.0067) and smokers with greater numbers of total variant alleles had improved overall survival (P = 0.040).
Conclusion: These results suggest that DNA repair gene polymorphisms may not influence RCC susceptibility, but that some of them may influence RCC progression, especially in smokers, possibly due to altered DNA repair capacity by these polymorphisms.
Key words: disease progression, DNA repair, genetic polymorphism, renal cell carcinoma, smoking, survival
Received for publication February 8, 2007. Revision received May 14, 2007. Accepted for publication May 25, 2007.
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