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Annals of Oncology Advance Access originally published online on April 13, 2007
Annals of Oncology 2007 18(11):1774-1781; doi:10.1093/annonc/mdm108
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© 2007 European Society for Medical Oncology

reviews

The expanding role of PET technology in the management of patients with colorectal cancer

R. A. Herbertson1,2,*, S. T. Lee1,3,4, N. Tebbutt1,2 and A. M. Scott1,3,4

1 Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences
2 Ludwig Institute Oncology Unit
3 Centre for Positron Emission Tomography
4 Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

* Correspondence to: Dr R. A. Herbertson, Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, 1st Floor, Harold Stokes Building, Austin Hospital, 145 Studley Road, Heidelberg, Victoria 3084 Australia. Tel: +61-394963098; Fax: +61-94965892; E-mail: rebecca.herbertson{at}ludwig.edu.au

The therapeutic options and subsequent survival of colorectal cancer (CRC) patients has increased substantially over recent years. While surgical excision of the primary cancer results in cure of ~50% of patients, recurrence and metastatic disease still remains a significant cause of death. Although resection of liver or lung metastases can result in cure, relapse rates remain high, indicating that patient selection needs improvement. Positron emission tomography (PET) technology has a great deal to offer with respect to CRC management, particularly in the setting of patient selection for metastasectomy and in the evaluation of possible recurrent disease, however it has not yet become a routine part of the management of all CRC patients. This review article aims to discuss the current and future implications of PET technology in the optimal management of CRC patients throughout their care pathway.

Key words: colorectal cancer, positron emission tomography

Received for publication January 21, 2007. Revision received February 20, 2007. Accepted for publication February 20, 2007.


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