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Annals of Oncology Advance Access originally published online on August 20, 2007
Annals of Oncology 2007 18(10):1734-1742; doi:10.1093/annonc/mdm188
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© 2007 European Society for Medical Oncology

pediatric malignancies

Up-to-date monitoring of childhood cancer long-term survival in Europe: central nervous system tumours

V. Arndt1,*, P. Kaatsch2, E. Steliarova-Foucher3, R. Peris-Bonet4 and H. Brenner1

1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
2 German Childhood Cancer Registry, University of Johannes Gutenberg, Mainz, Germany
3 Data Analysis and Interpretation Group, International Agency for Research on Cancer, Lyon, France
4 National Childhood Cancer Registry Spain (RNTI-SEOP) and Instituto López Piñero (CSIC Universitat de València), Valencia, Spain

* Correspondence to: Dr V. Arndt, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D-69115 Heidelberg, Germany. Tel: +49-6221-548144; Fax: +49-6221-548142; E-mail: v.arndt{at}dkfz-heidelberg.de

Background: Tumours of the central nervous system (CNS) account for 15–20% of all malignant childhood tumours in developed countries. Steady improvement of survival of children with CNS tumours has been reported for the past decades. However, these results, obtained by cohort analysis of survival, do not reflect the full extent of recent improvement.

Methods: Using selected registries from the database of the Automated Childhood Cancer Information System (ACCIS), we calculated period survival estimates for the years 1995–99 for children diagnosed with a malignant CNS tumour.

Results: The overall 10-year period survival estimate for the years 1995–99 was 59% for children with all CNS tumours combined, 73% for children with astrocytoma, 53% for children with ependymoma and 45% for children with primitive neuroectodermal tumours. On average, estimates derived by cohort analysis (pertaining to children diagnosed in 1985–89) were around 4% units lower. Region-specific analysis revealed that recent progress was largest in Eastern Europe, where prognosis nevertheless remained lower than in other European regions. In Northern and Southern Europe, 10-year survival remained essentially unchanged.

Conclusion: Although period survival of children with CNS tumours is higher than previously reported cohort survival, their long-term prognosis remains modest compared to other childhood malignancies.

Key words: cancer registries, childhood cancer, CNS tumours, Europe, population-based, prognosis, survival

Received for publication November 17, 2006. Revision received April 4, 2007. Accepted for publication April 11, 2007.


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