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Annals of Oncology Advance Access originally published online on September 5, 2007
Annals of Oncology 2007 18(10):1722-1733; doi:10.1093/annonc/mdm189
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© 2007 European Society for Medical Oncology

pediatric malignancies

Up-to-date monitoring of childhood cancer long-term survival in Europe: tumours of the sympathetic nervous system, retinoblastoma, renal and bone tumours, and soft tissue sarcomas

V. Arndt1,*, B. Lacour2, E. Steliarova-Foucher3, C. Spix4, A. Znaor5, G. Pastore6, C. Stiller7 and H. Brenner1

1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
2 French National Registry of Childhood Solid Tumours, Children's Hospital, Vandoeuvre, France
3 Data Analysis and Interpretation Group, International Agency for Research on Cancer, Lyon, France
4 German Childhood Cancer Registry, University of Johannes Gutenberg, Mainz, Germany
5 Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia
6 Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit of the Centre for Cancer Epidemiology and Prevention, CeRMS/FIRMS, Torino, Italy
7 Childhood Cancer Research Group, University of Oxford, UK

* Correspondence to: Dr V. Arndt, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D-69115 Heidelberg, Germany. Tel: +49-6221-548144; Fax: +49-6221-548142; E-mail: v.arndt{at}dkfz-heidelberg.de

Background: Prognosis for most types of childhood tumours has improved during the last few decades. In this article we estimate up-to-date period survival for less common, but important childhood malignancies in Europe.

Methods: Using the database of the Automated Childhood Cancer Information System we calculated period estimates of 10-year survival for the 1995–1999 period for children aged 0–14 years diagnosed during 1985–1999 with tumours of the sympathetic nervous system (NS), retinoblastoma, renal tumours, bone tumours and soft tissue sarcomas in four European regions.

Results: Ten-year period survival for 1995–1999 was 66% in children with tumours of the sympathetic NS, 96% for retinoblastoma, 87% for renal tumours, 58% for bone tumours and 61% for soft tissue sarcomas. The higher period estimates, as compared with cohort and complete estimates indicate recent improvement in survival for tumours of the sympathetic NS and to a lesser extent for retinoblastoma and renal tumours. Region-specific period survival estimates were lowest for Eastern Europe for renal, bone and soft tissue tumours, but not for the other two tumour groups.

Conclusion: There have been further improvements in the 1990s in long-term survival of children diagnosed with several malignancies, albeit to a different extent in different European regions.

Key words: cancer registries, childhood cancer, Europe, population-based, prognosis, survival, neuroblastoma, retinoblastoma, Wilms' tumour, bone tumours, soft tissue sarcomas

Received for publication November 17, 2006. Revision received April 4, 2007. Accepted for publication April 11, 2007.


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