Annals of Oncology Advance Access originally published online on October 17, 2006
Annals of Oncology 2007 18(1):143-148; doi:10.1093/annonc/mdl352
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© 2006 European Society for Medical Oncology
hematologic malignancies |
Alcohol consumption and risk of Hodgkin's lymphoma and multiple myeloma: a multicentre case–control study
1 Istituto Toscano Tumori, Environmental and Occupational Epidemiology Unit, Centre for Study and Prevention of Cancer, Florence
2 Epidemiology and Biostatistics Unit, National Cancer Research Institute, Genoa
3 National Cancer Institute Regina Elena, Rome
4 Oncology Department, Azienda USL Forlì, Forlì
5 Azienda Ospedaliera, Verona
6 Cancer registry & Pathology Unit, Azienda Ospedaliera "Civile M.P. Arezzo," Ragusa
7 Epidemiology Unit, National Cancer Institute, Milan
8 Pathology Institute, University of Siena, Siena
9 Local Health Unit, Novara
10 Cancer Epidemiology Unit, University of Turin, Italy
11 Imperial College—London, UK
* Correspondence to: Dr G. Gorini, Istituto Toscano Tumori, Environmental and Occupational Epidemiology Unit, Centre for Study and Prevention of Cancer, via di S. Salvi, 12-50135 Florence, Italy. Tel: +39-055-6268-347/345; Fax: +39-055-6268385/679954; E-mail: g.gorini{at}cspo.it
Background: Few studies have analysed the association between alcohol intake and Hodgkin's lymphoma (HL) or multiple myeloma (MM) risks.
Materials and methods: A multicentre population-based case–control study of 363 HL, 270 MM cases, and 1771 controls offered the opportunity to evaluate the relationship between alcohol and HL/MM risks. Unconditional logistic regression was carried out to estimate odds ratios (ORs) and 95% confidence intervals (CIs), associated with alcohol intake (servings per week, grams per day of ethanol intake) or duration of exposure (year).
Results: For HL, considering nonsmokers only, ever drinkers had a significantly decreased risk than never drinkers (OR = 0.46). Significantly lower risks in all levels of total alcohol intake were also detected, considering servings per week (OR for one to four servings per week = 0.51, 95% CI 0.32–0.82; OR for five to nine servings per week = 0.39, 95% CI 0.21–0.73; OR for 10–19 servings per week = 0.26, 95% CI 0.12–0.54; OR for 
20 servings per week = 0.34, 95% CI 0.15–0.79) and grams per day of ethanol intake (OR for 0.1–9.0 g/day = 0.45, 95% CI 0.27–0.74; OR for 9.1–17.9 g/day = 0.52, 95% CI 0.30–0.90; OR for 18.0–31.7 g/day = 0.27, 95% CI 0.13–0.57; OR for >31.7 g/day = 0.35, 95% CI 0.15–0.79). In the analysis for ever-smoking HL cases and controls, ever drinkers had the same risk as never drinkers. For MM, ever drinkers had a non-significantly decreased risk than non-drinkers (OR = 0.74), and ORs in almost all consumption levels were not significant (OR for 0.1–9.0 g/day = 0.93; OR for 9.1–17.9 g/day = 0.82; OR for 18.0–31.7 g/day = 0.47; 95% CI 0.28–0.81; OR for >31.7 g/day = 0.68). For HL and MM, the beverage type did not affect the risk significantly, and no consistent dose–response relationships were found, considering intensity or duration of alcohol consumption.
Conclusions: Our study indicates a protective effect of alcohol consumption for nonsmoking HL cases.
Key words: alcohol, case–control study, Hodgkin's lymphoma, multiple myeloma
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  S Deandrea, P Bertuccio, L Chatenoud, S Franceschi, D Serraino, and C La Vecchia Reply to 'Alcohol consumption and risk of Hodgkin's lymphoma and multiple myeloma: a multicentre case-control study' by Gorini et al. Ann. Onc., June 1, 2007; 18(6): 1119 - 1121. [Full Text] [PDF]
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