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Annals of Oncology 2006 17(Supplement 7):vii41-vii45; doi:10.1093/annonc/mdl948
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© 2006 European Society for Medical Oncology

symposium article

Detection and quantification of mammaglobin in the blood of breast cancer patients: can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study

G. Gargano1,#, V. Agnese1,#, V. Calò1, S. Corsale1, C. Augello1, L. Bruno1, L. La Paglia1, A. Gullo2, L. Ottini3, A. Russo1, F. Fulfaro1, G. Rinaldi1, A. Crosta1, G. Cicero1, O. Majorana1, L. Palmeri4, C. Cipolla5, A. Agrusa6, G. Gulotta6, V. Morello2, G. Di Fede1, V. Adamo7, G. Colucci8, R. M. Tomasino2, M. R. Valerio1, V. Bazan1 and Antonio Russo1,*

1 Section of Medical Oncology and 5 Section of Surgical Oncology, Department of Surgical and Oncology,Università di Palermo; 2 Cattedra di Oncologia Medica, Deparment od Surgery and Oncology, Università di Palermo; 3 Department of Human Pathology, Università di Palermo; 4 Dipartimento di Medicina Sperimentale e Patologia, Università di Roma ‘La Sapienza’; 6 Unit of General Surgery, Università di Palermo; 7 Unit of Medical Oncology, A.O.Universitaria Policlinico ‘G.Martino’, Università di Messina; 8 Division of Medical Oncology, National Institute of Oncology, Bari, Italy

* Correspondence to: Dr A. Russo, Section of Medical Oncology, Department of Oncology, Università di Palermo, Via del Vespro 127, 90127 Palermo, Italy. Tel: +39-091-6552500; Fax: +39-091-6554529; E-mail: lab-oncobiologia{at}usa.net

Background: Mammaglobin is expressed mainly in mammary tissue, overexpressed in breast cancer (BC) and rarely in other tissue. The aim of this study was to assess the sensitivity and specificity of transcript MGB1 detection and to evaluate the role of MGB1 as potential clinical marker for the detection of disseminated cancer cells in the blood of BC patients.

Patients and methods: A consecutive series of 23 BC tissues, 36 peripheral blood BC samples and 35 healthy peripheral blood samples was prospectively recruited to investigate MGB1 expression by means of a quantitative Real Time RT-PCR assay.

Results: MGB1 overexpression in tissue samples of BC patients is significantly associated only with high level of Ki67 (P <0.05). None of the samples from peripheral blood of 35 healthy female individuals were positive for MGB1 transcript. In contrast MGB1 mRNA expression was detected in three of 36 (8%) peripheral blood of BC patients.

Conclusions: Our preliminary results demonstrate that the detection of MGB1 transcript in peripheral blood of BC patients was specific but with low sensitivity. MGB1 overexpression by itself or in combination with Ki67 might be considered an index of BC progression.

Key words: mammaglobin (MGB1), breast cancer, disseminated cancer cells, real time RT-PCR


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