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Annals of Oncology 2006 17(Supplement 7):vii137-vii141; doi:10.1093/annonc/mdl967
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© 2006 European Society for Medical Oncology

symposium article

Significance of P16INK4A hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study

V. Agnese1,#, S. Corsale1,#, V. Calò1, C. Augello1, L. Bruno1, D. Calcara1, A. Crosta1, V. Rodolico1, G. Rinaldi1, G. Cicero1, F. Latteri2, A. Agrusa3, V. Morello4, V. Adamo1, G. Altavilla5, G. Di Fede1, E. Fiorentino2, N. Grassi2, M. A. Latteri2, M. R. Valerio1, R. M. Tomasino4, G. Colucci6, V. Bazan1 and A. Russo1,*

1 Section of Medical Oncology, 2 Section of Surgical Oncology, Department of Surgical and Oncology, 3 Section of General Surgery, 4 Department of Human Pathology, Università di Palermo; 5 Unit of Medical Oncology, A.O.Universitaria Policlinico ‘G.Martino’, Università di Messina; 6 Division of Medical Oncology, National Institute of Oncology, Bari, Italy; 7 Department of Medical Oncology, University of Messina, Italy

* Correspondence to: Dr A. Russo, Section of Medical Oncology, Department of Oncology, Università di Palermo, Via del Vespro 127, 90127 Palermo, Italy. Tel: +39-091-6552500; Fax: +39-091-6554529; E-mail: lab-oncobiologia{at}usa.net

Background: Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivation; its incidence is extremely variable according to the type of tumor involved. Our purpose was to analyze the hypermethylation of the p16 promoter in laryngeal squamous cell carcinomas (LSCC), salivary gland (SG) tumors and in colorectal cancer (CRC), to detect any possible association with the clinicopathological features and to determine the prognostic significance of the p16 gene in the tumors analyzed.

Patients and methods: The hypermethylation of the p16 promoter was prospectively analyzed, by MSP, in a consecutive series of 64 locally advanced LSCC patients, in a consecutive series of 33 SG tumor patients and in a consecutive series of 66 sporadic CRC patients.

Results: Hypermethylation was observed in 9% of the LSCC cases, in all cases of SG cancer and in 21% of the CRC cases. No significant association was observed between p16 hypermethylation and clinicopathological variables in all the tissue samples analyzed. Moreover at univariate analysis p16 mutations were not independently related at disease relapse and death in LSCC and CRC.

Conclusions: The results of this study suggest that the lack of p16 function could happen in advanced stage of SG tumors.

Key words: P16 hypermethylation, laryngeal squamous cell carcinoma, salivary gland cancer, colorectal cancer


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