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Annals of Oncology 2006 17(Supplement 5):v17-v19; doi:10.1093/annonc/mdj943
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© 2006 European Society for Medical Oncology

symposium article

In vitro studies on gemcitabine combinations with other antiblastics

E. Giovannetti, R. Danesi*, V. Mey, S. Nannizzi, G. Pasqualetti and M. Del Tacca

Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Italy

* Correspondence to: Dr R. Danesi, Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, 56126 Pisa, Italy. Tel: +39-050-830148; Fax: +39-050-562020; E-mail: r.danesi{at}med.unipi.it

The use of gemcitabine in combination with chemotherapeutic agents, including cisplatin, pemetrexed and taxanes, is characterized by the enhancement of their anticancer activity. The analysis of the underlying pharmacodynamics has revealed that modulation of nucleotide pools, drug metabolism, and cellular DNA repair capability are the most common factors to explain the additive to synergistic interaction between gemcitabine and anticancer agents in several human cancers in vitro and in vivo.

Key words: gemcitabine, metabolism, drug interaction


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