Skip Navigation


Annals of Oncology Advance Access originally published online on July 27, 2006
Annals of Oncology 2006 17(9):1399-1403; doi:10.1093/annonc/mdl161
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
17/9/1399    most recent
mdl161v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (25)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Giantonio, B.
Right arrow Articles by Benson, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giantonio, B.
Right arrow Articles by Benson, A., III
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 European Society for Medical Oncology

gastrointestinal tumors

A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: results from the eastern cooperative oncology group study E2200

BJ Giantonio1,*, DE Levy2, PJ O'Dwyer1, NJ Meropol3, PJ Catalano2 and AB Benson, III4

1 University of Pennsylvania, Philadelphia, PA
2 Dana-Farber Cancer Institute, Boston, MA
3 Fox Chase Cancer Center, Philadelphia, PA
4 Northwestern University, Chicago, IL, USA

*Correspondence to: Dr B. Giantonio, University of Pennsylvania, 3400 Spruce St., 12 Penn Tower, 19104 Philadelphia, PA, USA. Tel: +1 215 349-8967; Fax: +1 215 615-3380; E-mail: giantonio.bruce{at}jimmy.harvard.edu

Aim: Patients with untreated advanced colorectal cancer were enrolled to this single arm phase II multi-center cooperative group trial of bevacizumab combined with IFL. The first 20 patients received irinotecan (125 mg/m2), 5-fluorouracil (500 mg/m2) and leucovorin (20 mg/m2) weekly for four of six weeks and high-dose bevacizumab (10 mg/kg) every other week. Following a toxicity review of other trials using IFL, subsequent patients were enrolled at reduced doses of irinotecan (100 mg/m2) and 5-fluorouracil (400 mg/m2).

Results: Of the 92 patients accrued to the study, toxicity data are available for 87 patients and efficacy data for 81 patients. At a median follow-up of 37.5 months, median overall survival is 26.3 months, median progression free survival is 10.7 months and 1-year survival is 85%. The overall response rate is 49.4% (6.2% complete responses). A reduction in the starting doses of irinotecan and 5-fluorouracil decreased the occurrence of vomiting, diarrhea and neutropenia related complications. Bleeding occurred in 37 patients; all events but two were grade 1 or grade 2. There were nine reports of grade 3 or grade 4 thrombo-embolic events. Hypertension of any grade occurred in 13% of patients and proteinuria was infrequent.

Conclusion: High-dose bevacizumab added to IFL is a well-tolerated and highly active regimen in patients with previously untreated metastatic colorectal cancer.

Key words: first-line therapy, high-dose bevacizumab, IFL, metastatic colorectal cancer


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J Health Syst PharmHome page
S. S. Shord, L. R. Bressler, L. A. Tierney, S. Cuellar, and A. George
Understanding and managing the possible adverse effects associated with bevacizumab
Am. J. Health Syst. Pharm., June 1, 2009; 66(11): 999 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
K. KOLINSKY, Y.-E ZHANG, U. DUGAN, D. HEIMBROOK, K. PACKMAN, and B. HIGGINS
Novel Regimens of Capecitabine Alone and Combined with Irinotecan and Bevacizumab in Colorectal Cancer Xenografts
Anticancer Res, January 1, 2009; 29(1): 91 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncolHome page
C. P. Carden, J. M.G. Larkin, and M. A. Rosenthal
What is the risk of intracranial bleeding during anti-VEGF therapy?
Neuro-oncol, August 1, 2008; 10(4): 624 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
R. Brake, C. Starnes, J. Lu, D. Chen, S. Yang, R. Radinsky, and L. Borges
Effects of Palifermin on Antitumor Activity of Chemotherapeutic and Biological Agents in Human Head and Neck and Colorectal Carcinoma Xenograft Models
Mol. Cancer Res., August 1, 2008; 6(8): 1337 - 1346.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
P. M. Winter, A. H. Schmieder, S. D. Caruthers, J. L. Keene, H. Zhang, S. A. Wickline, and G. M. Lanza
Minute dosages of {alpha}{nu}{beta}3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits
FASEB J, August 1, 2008; 22(8): 2758 - 2767.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. Pfannschmidt, H. Dienemann, and H. Hoffmann
Surgical Resection of Pulmonary Metastases From Colorectal Cancer: A Systematic Review of Published Series
Ann. Thorac. Surg., July 1, 2007; 84(1): 324 - 338.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. Heiduschka, H. Fietz, S. Hofmeister, S. Schultheiss, A. F. Mack, S. Peters, F. Ziemssen, B. Niggemann, S. Julien, K. U. Bartz-Schmidt, et al.
Penetration of Bevacizumab through the Retina after Intravitreal Injection in the Monkey
Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2814 - 2823.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
M. Los, J. M. L. Roodhart, and E. E. Voest
Target Practice: Lessons from Phase III Trials with Bevacizumab and Vatalanib in the Treatment of Advanced Colorectal Cancer
Oncologist, April 1, 2007; 12(4): 443 - 450.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
S. Senan and E. F. Smit
Design of Clinical Trials of Radiation Combined with Antiangiogenic Therapy
Oncologist, April 1, 2007; 12(4): 465 - 477.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
S. Gill, A. W. Blackstock, and R. M. Goldberg
Colorectal Cancer
Mayo Clin. Proc., January 1, 2007; 82(1): 114 - 129.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.