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Annals of Oncology Advance Access originally published online on June 20, 2006
Annals of Oncology 2006 17(9):1393-1398; doi:10.1093/annonc/mdl136
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© 2006 European Society for Medical Oncology

breast cancer

Baseline MRI delivery characteristics predict change in invasive ductal breast carcinoma PET metabolism as a result of primary chemotherapy administration

SIK Semple1,*, RT Staff2, SD Heys3, TW Redpath1, AE Welch4, TS Ahearn1, AW Hutcheon5 and FJ Gilbert1

1 Department of Radiology, University of Aberdeen, Scotland, UK
3 Department of Surgery, University of Aberdeen, Scotland, UK
4 Department of School of Medical Sciences, University of Aberdeen, Scotland, UK
2 Department of Nuclear Medicine, Grampian University Hospitals NHS Trust, Foresterhill, Aberdeen, Scotland, UK
5 Department of Clinical Oncology, Aberdeen Royal Infirmary, Grampian University Hospitals NHS Trust, Foresterhill, Aberdeen, Scotland, UK

*Correspondence to: Dr S. I. K. Semple, Lilian Sutton Building, Department of Radiology, University of Aberdeen AB25 2ZD, Scotland, UK. Tel: +44-1224559725; Fax: +44-1224559718; E-mail: s.semple{at}abdn.ac.uk

Background: The aim of the study was to investigate whether pre-therapy vascular delivery assessment [using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)] can predict reduction in breast cancer metabolism [detected using 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (18F–FDG-PET)] after a single cycle of chemotherapy. Reduction in 18F-FDG PET metabolism has previously been shown to correlate with histological response to primary chemotherapy.

Patients and methods: Seventeen patients with large or locally advanced invasive ductal carcinomas of the breast were imaged using DCE-MRI and 18F-FDG-PET prior to therapy and 20 days after the first cycle of chemotherapy. MRI data were analysed using a multi-compartment model. PET data were analysed using standardised uptake value (SUV) analysis.

Results: A significant association (P <0.05) was observed between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism resulting from administration of one cycle of chemotherapy.

Conclusions: A relationship was demonstrated between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism after a single cycle of chemotherapy. This suggests that reduction in PET metabolism as a result of chemotherapy may be dependent, at least in part, on pre-therapy vascular delivery. These pre-therapy vascular characteristics may be suitable for use as a surrogate measure for initial chemotherapy delivery, a key factor in chemotherapeutic efficacy.

Key words: breast cancer, dynamic MRI, 18F-FDG PET, chemotherapy, efficacy, delivery


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