Skip Navigation


Annals of Oncology Advance Access originally published online on November 25, 2005
Annals of Oncology 2006 17(3):437-442; doi:10.1093/annonc/mdj090
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
17/3/437    most recent
mdj090v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Chong, G.
Right arrow Articles by Carmichael, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chong, G.
Right arrow Articles by Carmichael, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 European Society for Medical Oncology

Phase III trial of 5-fluorouracil and leucovorin plus either 3H1 anti-idiotype monoclonal antibody or placebo in patients with advanced colorectal cancer

G. Chong1, A. Bhatnagar2, D. Cunningham1,*, T. M. Cosgriff3, P. G. Harper4, W. Steward5, J. Bridgewater6, M. Moore7, J. Cassidy8, R. Coleman9, F. Coxon10, C. H. Redfern11, J. J. Jones12, R. Hawkins13, D. Northfelt14, S. Sreedharan2, F. Valone2 and J. Carmichael15

1 Royal Marsden Hospital, Sutton, Surrey, UK; 2 Titan Pharmaceuticals, South San Francisco, CA, USA; 3 Hematology and Oncology Services, New Orleans, LA, USA; 4 Guys Hospital, London, UK; 5 Leicester Royal Infirmary, Leicester, UK; 6 North Middlesex Hospital, Edmonton, UK; 7 Georgia Cancer Research Center, Decatur, GA, USA; 8 University of Aberdeen, Aberdeen, UK; 9 Weston Park Hospital NHS Trust, Sheffield, UK; 10 Newcastle General Hospital, Newcastle-upon-Tyne, UK; 11 Sharp Health Care, San Diego, CA, USA; 12 Columbus CCOP, Columbus, OH, USA; 13 Christie Hospital, Withington, UK; 14 University of California, San Diego, CA, USA; 15 City Hospital, Nottingham, UK

* Correspondence to: Dr. D. Cunningham, Department of Medicine, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK. Tel: +44-20-86613156; Fax: +44-20-86439414; E-mail: david.cunningham{at}icr.ac.uk

Background: The monoclonal antibody 3H1 mimics the external structure of the carcinoembryonic antigen (CEA). It therefore has the potential, via the anti-idiotypic network, to stimulate immune responses to CEA that may benefit colorectal cancer patients.

Patients and methods: A total of 630 patients with previously untreated metastatic colorectal cancer were randomised in a 2:1 fashion to receive bolus 5-fluorouracil (5-FU) and leucovorin (LV) plus either 3H1 (n = 422) or placebo (n = 208).

Results: The addition of 3H1 to 5-FU and LV did not result in increased toxicity. Survival for the full intent-to-treat population was 14.7 months for the 3H1 arm and 15.2 months for the placebo arm (P = 0.80). Anti-CEA antibody responses were observed in 70% of patients treated with 3H1. Patients with a negative CEA response had a median survival of 8.3 months (95% CI 7.5–11.0) compared with patients with a strong response: median survival not reached (P <0.001).

Conclusion: 3H1 is safe and effectively induces immune responses to CEA. Addition of 3H1 to 5-FU and LV was not shown to improve overall patient outcomes. However, improved survival in patients developing anti-CEA responses to 3H1 are provocative and should be studied in further clinical trials.

Key words: anti-idiotype, antibody, carcinoembryonic antigen, response, colorectal


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann OncolHome page
J Pfisterer, A du Bois, J Sehouli, S Loibl, S Reinartz, A Reuss, U Canzler, A Belau, C Jackisch, R Kimmig, et al.
The anti-idiotypic antibody abagovomab in patients with recurrent ovarian cancer. A phase I trial of the AGO-OVAR.
Ann. Onc., October 1, 2006; 17(10): 1568 - 1577.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.