Skip Navigation


Annals of Oncology Advance Access originally published online on November 17, 2005
Annals of Oncology 2006 17(2):262-269; doi:10.1093/annonc/mdj077
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
17/2/262    most recent
mdj077v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Nitti, D.
Right arrow Articles by Lise, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nitti, D.
Right arrow Articles by Lise, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 European Society for Medical Oncology

Randomized phase III trials of adjuvant FAMTX or FEMTX compared with surgery alone in resected gastric cancer. A combined analysis of the EORTC GI Group and the ICCG

D. Nitti1,*, J. Wils2, J. Guimaraes Dos Santos3, G. Fountzilas4, P. F. Conte5, C. Sava6, A. Tres7, R. C. Coombes8, D. Crivellari9, A. Marchet1, E. Sanchez3, J. M. Bliss10, J. Homewood10, M. L. Couvreur11, E. Hall10, B. Baron11, E. Woods8, M. Emson8, E. Van Cutsem12 and M. Lise1

1 Università di Padova, Clinica Chirurgica II, Padova, Italy; 2 Laurentius Hospital, Roermond, The Netherlands; 3 Instituto Portugues de Oncologia, Porto, Portugal; 4 Aristotle University of Thessaloniki, Macedonia, Greece; 5 University Hospital, Modena, Italy; 6 Regional Hospital, Treviso, Italy; 7 Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain; 8 Charing Cross Hospital, and International Collaborative Cancer Group (ICCG), Imperial College London, UK; 9 Centro di Riferimento Oncologico, Aviano, Italy; 10 Clinical Trials and Statistics Unit, Institute of Cancer Research, Sutton, UK; 11 European Organization for Research and Treatment of Cancer (EORTC), Data Center, Brussels, Belgium; 12 University Hospital Gasthuisberg, Leuven, Belgium

* Correspondence to: Prof. D. Nitti, Clinica Chirurgica II, Via Giustiniani 2, Padova, I-35128, Italy; Tel: +39-049-8212073/8212055, Fax: +39-049-651891; E-mail: donato.nitti{at}unipd.it

Background: In patients who underwent radical resection for gastric cancer, we investigate the relative efficacy of combined 5-fluorouracil + adriamycin or epirubicin and methotrexate with leucovorin rescue (FAMTX or FEMTX) compared with a control arm.

Patients and methods: This report is a prospective combined analysis of two randomized clinical trials conducted on patients who underwent radical resection for histologically proven adenocarcinoma of the stomach or esophago-gastric junction. Three hundred and ninety-seven untreated patients, 206 from 23 European Organization for Research and Treatment of Cancer (EORTC) institutions and 191 from 16 International Collaborative Cancer Group (ICCG) institutions, were randomized. Overall survival (OS) and disease-free survival (DFS) were estimated using the Kaplan–Meier method and the treatments were compared for these end-points by means of the log-rank test, retrospectively stratified by trial.

Results: In a planned combined analysis of the two trials, no significant differences were found between the treatment and control arms for either DFS (hazards ratio: 0.98, P = 0.87) or OS (hazards ratio: 0.98, P = 0.86). The 5-year OS was 43% in the treatment arm and 44% in the control arm and the 5-year DFS was 41% and 42%, respectively.

Conclusion: Neither FAMTX nor FEMTX can be advocated as adjuvant treatment in patients who undergo resection for gastric cancer.

Key words: adjuvant chemotherapy, FAMTX, FEMTX, gastric cancer


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JNCI J Natl Cancer InstHome page
F. Di Costanzo, S. Gasperoni, L. Manzione, G. Bisagni, R. Labianca, S. Bravi, E. Cortesi, P. Carlini, R. Bracci, S. Tomao, et al.
Adjuvant Chemotherapy in Completely Resected Gastric Cancer: A Randomized Phase III Trial Conducted by GOIRC
J Natl Cancer Inst, March 19, 2008; 100(6): 388 - 398.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. Wu and J. Ji
Adjuvant Chemotherapy for Gastric Cancer or Not: A Dilemma?
J Natl Cancer Inst, March 19, 2008; 100(6): 376 - 377.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.