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Annals of Oncology Advance Access originally published online on May 19, 2005
Annals of Oncology 2005 16(8):1381-1390; doi:10.1093/annonc/mdi238
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© 2005 European Society for Medical Oncology

Antimicrobial prophylaxis in allogeneic bone marrow transplantation. Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Oncology

W. H. Krüger1,*, J. Bohlius2, O. A. Cornely2, H. Einsele3, H. Hebart3, G. Massenkeil4, S. Schüttrumpf5, G. Silling6, A. J. Ullmann7, D. T. Waldschmidt8 and H.-H. Wolf9

1 Medizinische Klinik C, Greifswald, Germany; 2 Klinik I für Innere Medizin, Klinische Infektiologie, Klinikum der Universität zu Köln, Köln, Germany; 3 Medizinische Klinik II, Abt. Hämatologie/Onkologie/Immunologie, Eberhard-Karls-Universität, Tübingen, Germany; 4 Klinik für Hämatologie und Onkologie,Universitätsklinik Charité, Campus Virchow-Klinikum, Berlin, Germany; 5 Zentrum Innere Medizin, Abteilung für Hämatologie/Onkologie, Georg-August-Universität Göttingen, Göttingen, Germany; 6 Medizinische Klinik A – KMT-Zentrum, Westfälische-Wilhelms-Universität, Münster, Germany; 7 Medizinische Klinik und Poliklinik, Klinikum der Johannes Gutenberg-Universität, Mainz, Germany; 8 Klinik IV für Innere Medizin, Klinikum der Universität zu Köln, 9 Klinik für Innere Medizin IV, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany

* Correspondence to: Dr W. H. Krüger, Medizinische Klinik C (Hämatologie und Onkologie, Transplantationszentrum), Ernst-Moritz-Arndt-Universität-Greifswald, Ferdinand-Sauerbruch-Straße, 17487 Greifswald, Germany. Tel: +49-3834-86-22 007/22 006; Fax: +49-3834-86-22 012. Email: william.krueger{at}uni-greifswald.de

Patients undergoing allogeneic stem cell transplantation are at high risk for infection with a variety of pathogens during different phases of the procedure. Bacteria and fungi predominate the first phase until engraftment. During the second phase, from engraftment to about day 100, major infectious problems are caused by fungi and cytomegalovirus. Both pathogens remain important under continued immunosuppression, however, in the late post-transplantation period infections with encapsulated bacteria may become a problem. In this review the Infectious Diseases Working Party of the DGHO gives recommendations for prophylaxis of infections under allogeneic stem cell transplantation with drugs and other measures. The aim of the group was to do this on an evidence-based-medicine rating, if possible.


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