Annals of Oncology Advance Access originally published online on January 24, 2005
Annals of Oncology 2005 16(3):473-480; doi:10.1093/annonc/mdi093
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© 2005 European Society for Medical Oncology
FDG-PET scanning for detection and staging of extranodal marginal zone lymphomas of the MALT type: a report of 42 cases
Departments of 1 Radiation Oncology and 2 Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
* Correspondence to: Dr J. Yahalom, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10 021, USA. Tel: +1-212-639-5999; Fax: +1-212-639-7742; Email: yahalomj{at}mskcc.org
Background: Although reports have suggested that FDG-PET scans were not useful for staging of extranodal marginal zone lymphomas (MZL), experience at our center suggests otherwise. Thus we reviewed the findings of FDG-PET scans in patients with extranodal MZL seen at our center.
Patients and methods: A database of 175 patients with histologically-confirmed diagnoses of extranodal MZL was reviewed. Forty-two patients who had had FDG-PET scans for initial staging were identified. All information was obtained by retrospective review of medical records and PET scans.
Results: Thirty-four (81%) patients had focal tracer uptake within verified tumor sites, six (14%) patients did not, and two (5%) patients had indeterminate uptake. Seven of the 34 (21%) patients with uptake within verified tumor sites had uptake in regional lymph nodes and four patients were upstaged due to FDG-PET findings. Eight patients also obtained post-treatment FDG-PET scans. In five of those eight, the repeated FDG-PET scan indicated a complete response, and in three there was an indeterminate or mixed response.
Conclusion: FDG-PET scans carried out for initial staging of extranodal MZL detected disease in a high proportion of patients. This study suggests that imaging with FDG-PET scans is useful for both initial staging and follow-up of patients with extranodal MZL.
Key words: MALT lymphoma, PET scan
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