Skip Navigation

Annals of Oncology 2005 16(1):16-22; doi:10.1093/annonc/mdi004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (37)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Posadas, E. M.
Right arrow Articles by Kohn, E. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Posadas, E. M.
Right arrow Articles by Kohn, E. C.
Related Collections
Right arrow 2005 - Review Articles
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 European Society for Medical Oncology

Review

Proteomic analysis for the early detection and rational treatment of cancer—realistic hope?

E. M. Posadas1,2,*, F. Simpkins2, L. A. Liotta1,2, C. MacDonald2 and E. C. Kohn1,2

1 Laboratory of Pathology, National Cancer Institute and 2 NCI/FDA Clinical Proteomics Program, Bethesda, MD, USA

* Correspondence to: Dr E. M. Posadas, Building 10, Room 12N226, 10 Center Drive MSC 1906, Bethesda, MD 20892-1906, USA. Tel: +1-301-451-4982; Fax: +1-301-402-0172; Email: posadase{at}mail.nih.gov

Proteomics is an emerging field in medical science focused on the library of proteins specific to a given biosystem, the proteome, and understanding relationships therein. This field incorporates technologies that can be applied to serum and tissue in order to extract important biological information to aid clinicians and scientists in understanding the dynamic biology of their system of interest, such as a patient with cancer. These tools include laser capture microdissection, tissue lysate arrays and mass spectrometry approaches. These new technologies are more potent coupled with advanced bioinformatics analysis. They are used to characterize the content of, and changes in, the proteome induced by physiological changes, benign and pathologic. The application of these tools has assisted in the discovery of new biomarkers and may lead to new diagnostic tests and improvements in therapeutics. These tools additionally can provide a molecular characterization of cancers, which may allow for individualized molecular therapy. Understanding the basic concepts and tools used will illustrate how best to apply these technologies for patient benefit for the early detection of cancer and improved patient care.

Key words: cancer, early detection, laser capture microdissection, proteomics, surface-enhanced laser desorption ionization, tissue lysate arrays


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mayo Clin Proc.Home page
J. E. Heffner and J. S. Klein
Recent Advances in the Diagnosis and Management of Malignant Pleural Effusions
Mayo Clin. Proc., February 1, 2008; 83(2): 235 - 250.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. Lance
The Cancer Genome and Diagnostic Blood Tests.
Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2017 - 2018.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
N. Li, R. Guo, W. Li, J. Shao, S. Li, K. Zhao, X. Chen, N. Xu, S. Liu, and Y. Lu
A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide
Carcinogenesis, June 1, 2006; 27(6): 1222 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
B. W. Robinson and R. A. Lake
Advances in malignant mesothelioma.
N. Engl. J. Med., October 13, 2005; 353(15): 1591 - 1603.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Espana, B. Martin, R. Aragues, C. Chiva, B. Oliva, D. Andreu, and A. Sierra
Bcl-xL-Mediated Changes in Metabolic Pathways of Breast Cancer Cells: From Survival in the Blood Stream to Organ-Specific Metastasis
Am. J. Pathol., October 1, 2005; 167(4): 1125 - 1137.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.