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Annals of Oncology 2004 15(9):1432-1438; doi:10.1093/annonc/mdh354
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© 2004 European Society for Medical Oncology

Original Article

Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma

S. Yamamoto1, Y. Tomita2,*, Y. Hoshida2, S. Toyosawa3, H. Inohara4, M. Kishino3, M. Kogo5, M. Nakazawa5, S. Murakami6, N. Iizuka2, S. Kidogami2, M. Monden1, T. Kubo4, N. Ijuhin3 and K. Aozasa2

1 Department of Surgery and Clinical Oncology, 2 Department of Pathology, 4 Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Suita, Osaka; 3 Department of Oral Pathology, 5 Department of Oral and Maxillofacial Surgery, 6 Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan

* Correspondence to: Dr Y. Tomita, Department of Pathology (C3), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. Tel: +81 6 6879 3711; Fax: +81 6 6879 3719; Email: yt{at}molpath.med.osaka-u.ac.jp

Background: Valosin-containing protein (VCP) is associated with anti-apoptotic function and metastasis via activation of the nuclear factor-{kappa}B signaling pathway. In the present study, association of VCP expression with prognosis of gingival squamous cell carcinoma (GSCC) was examined.

Patients and methods: VCP expression in 74 patients with GSCC (34 males and 40 females) with ages ranging from 42 to 85 (median 66) years was evaluated by immunohistochemistry, in which staining intensity in tumor cells was categorized as either weaker (level 1) or equal to/stronger (level 2) than that in the endothelial cells.

Results: Twenty-four (32.4%) cases showed level 1 and 50 (67.6%) level 2 VCP expression. Patients with level 1 GSCC showed a significantly better 5-year survival rate than those with level 2 GSCC (5-year overall survival: 100% versus 84.9%, P<0.05). Multivariate analysis revealed VCP expression level, lymph node metastasis and pT(TNM) to be independent factors for overall survival. Patients with GSCC at stages I and II showed favorable prognosis regardless of VCP expression status, whereas at stages III and IV, patients with level 1 VCP expression showed better survival rates than those with level 2 expression.

Conclusion: Prognostic significance of VCP expression level in GSCC was demonstrated.

Key words: gingival squamous cell cancer, prognosis, valosin-containing protein


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