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Annals of Oncology 15:1161-1171, 2004
© 2004 European Society for Medical Oncology

Review

Primary chemotherapy for breast cancer: the evidence and the future

The first generation of randomised trials assessing the role of primary chemotherapy in breast cancer has failed to demonstrate the expected survival benefit. However, it has established the role of this treatment in ‘downstaging’ tumours of patients with locally advanced disease and, consequently, in improving breast conservation rates. Also, a number of surrogates of outcome have been identified, which will hopefully lead to earlier results in breast cancer clinical trials. Encouraging results have also been reported in trials investigating a number of novel approaches.

M. S. Mano1,* and A. Awada2

1 Beatson Oncology Centre, Department of Medical Oncology, Glasgow, UK; 2 Institut Jules Bordet, Unité de Chimiothérapie, Brussels, Belgium

* Correspondence to: Dr M. S. Mano, Beatson Oncology Centre, Department of Medical Oncology, Dumbarton Road, Glasgow G11 6NT, UK. Tel: +44-141-2116299; Fax: +44-141-2111866; E-mail: max_mano{at}hotmail.com

Key words: breast cancer, breast conserving surgery, neoadjuvant chemotherapy, primary chemotherapy


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