Annals of Oncology 15:613-617, 2004
© 2004 European Society for Medical Oncology
Original Paper |
Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome
Received 23 October 2003; revised 19 November 2003; accepted 22 December 2003Background:
The expression of CXCR4 has been implicated in metastatic dissemination in different models of breast cancer and melanoma. In the present study, we evaluated CXCR4 expression in non-small-cell lung cancer (NSCLC) and the relationship between CXCR4 expression and the prognosis of stage I disease.
Patients and methods:
Using immunohistochemical analysis, we retrospectively analyzed CXCR4 expression in specimens from 61 patients with completely resected pathologically confirmed stage I NSCLC for whom clinical follow-up data were available.
Results:
In the present study, we have shown that: CXCR4 is expressed by tumor cells in stage I NSCLC; CXCR4 is located in the nucleus and/or in the cytoplasm of tumor cells; strong nuclear staining was observed in 17 cases (29.8%); patients whose tumors had CXCR4-positive nuclear staining had a significantly longer duration of survival than patients whose tumors had no nuclear expression (P = 0.039, log-rank test). Interestingly, the 5-year metastasis rates were 23.5% and 34.1% in patients with CXCR4-positive and CXCR4-negative nuclear expression, respectively (P = 0.2).
Conclusion:
Strong CXCR4-positive nuclear staining was associated with a significantly better outcome in early-stage NSCLC. The mechanisms underlying this clinically and biologically important finding need to be further explored.
1 SOMPS, Pitié Salpetrière Hospital, Paris; 2 Départment de Médecine, Institut Gustave Roussy, Villejuif; 3 CEA-DSV/DRR/LRO, Fontenay aux Roses Cedex; 4 Laboratoire d‘Immunologie Cellulaire, Faculté de Médecine Pitié-Salpétrière; 5 Avicenne Hospital, Bobigny Cedex, France
Key words: chemokines, CXCR4, immunohistochemistry, lung cancer, prognostic factor
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